3-METHYLHISTIDINE EXCRETION AS AN INDEX OF MYOFIBRILLAR PROTEIN CATABOLISM IN NEUROMUSCULAR DISEASE
3-METHYLHISTIDINE EXCRETION AS AN INDEX OF MYOFIBRILLAR PROTEIN CATABOLISM IN NEUROMUSCULAR DISEASE
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DOI：
10.1136/jnnp.42.6.536
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发表时间：
1979-01-01
影响因子：
11
通讯作者：
ROYSTON, P
中科院分区：
文献类型：
--
作者：
MCKERAN, RO;HALLIDAY, D;ROYSTON, P
在各种神经肌肉疾病中，肌原纤维蛋白催化剂是根据尿液中3-甲基组氨酸的排泄量计算的。在Duchenne型肌营养不良症、运动神经元病、多发性肌炎和甲亢性肌病中显著升高。在Becker型肌营养不良症中，水平略有升高。肩胛腓及肢带营养不良、营养不良性肌强直、锥体外系病、多发性硬化症均正常。在甲状腺功能减退性肌病中显著降低。
Myofibrillar protein catabolism was calculated in a variety of neuromuscular diseases from the amount of 3-methylhistidine excreted in the urine. It was significantly raised in Duchenne type muscular dystrophy, motor neuron disease, polymyositis and thyrotoxic myopathy. In Becker type muscular dystrophy the level was slightly raised. It was normal in scapuloperoneal and limb girdle dystrophy, dystrophia myotonica, extrapyramidal disease and multiple sclerosis. It was significantly decreased in hypothyroid myopathy.