EPO induces changes in synaptic transmission and plasticity in the dentate gyrus of rats
EPO induces changes in synaptic transmission and plasticity in the dentate gyrus of rats
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DOI：
10.1002/syn.21895
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发表时间：
2016-06-01
期刊：
影响因子：
2.3
通讯作者：
Bergado, Jorge A.
中科院分区：
文献类型：
--
作者：
Almaguer-Melian, William;Merceron-Martinez, Daymara;Bergado, Jorge A.
促红细胞生成素在疾病动物模型和健康动物中对中枢神经系统显示出广泛的生理作用。我们最近的研究表明，在日常水迷宫训练后15分钟（而不是5小时），系统给药EPO能够诱导穹窿毡慢性损伤动物的空间记忆恢复，这表明急性EPO触发机制可以调节损伤动物空间记忆获取的活跃神经可塑性机制。此外，这种EPO效应伴随着可塑性相关早期基因的上调。更值得注意的是，这种对学习恢复的时间依赖性效应可能表明神经系统中的EPO调节了特定的活细胞过程。在本文中，我们关注EPO是否可以像LTP和LTD一样调节长期突触可塑性的诱导，这可能支持我们之前发表的数据。我们的研究结果表明，在突触可塑性诱导前15分钟，急性EPO外周给药能够增加LTP的大小（在PSA中比fEPSP-Slope更突出），从而促进LTD的诱导，并保护LTP免于去增强。这些发现表明EPO调节体内突触可塑性，支持EPO不仅可以作为神经保护物质，还可以调节短暂的神经可塑性机制，从而促进慢性脑损伤后神经功能的恢复。根据这些结果，EPO可以作为神经修复治疗的分子工具。中文信息学报，2016。(c) 2016 Wiley Periodicals, Inc.；
Erythropoietin has shown wide physiological effects on the central nervous system in animal models of disease, and in healthy animals. We have recently shown that systemic EPO administration 15 min, but not 5 h, after daily training in a water maze is able to induce the recovery of spatial memory in fimbria-fornix chronic-lesioned animals, suggesting that acute EPO triggers mechanisms which can modulate the active neural plasticity mechanism involved in spatial memory acquisition in lesioned animals. Additionally, this EPO effect is accompanied by the up-regulation of plasticity-related early genes. More remarkably, this time-dependent effects on learning recovery could signify that EPO in nerve system modulate specific living-cellular processes. In the present article, we focus on the question if EPO could modulate the induction of long-term synaptic plasticity like LTP and LTD, which presumably could support our previous published data. Our results show that acute EPO peripheral administration 15 min before the induction of synaptic plasticity is able to increase the magnitude of the LTP (more prominent in PSA than fEPSP-Slope) to facilitate the induction of LTD, and to protect LTP from depotentiation. These findings showing that EPO modulates in vivo synaptic plasticity sustain the assumption that EPO can act not only as a neuroprotective substance, but is also able to modulate transient neural plasticity mechanisms and therefore to promote the recovery of nerve function after an established chronic brain lesion. According to these results, EPO could be use as a molecular tool for neurorestaurative treatments. Synapse 70:240-252, 2016. (c) 2016 Wiley Periodicals, Inc.