Could stroma contribute to field cancerization?
Could stroma contribute to field cancerization?
复制标题
基质会导致局部癌化吗？
DOI：
10.1016/j.mehy.2010.01.019
复制
发表时间：
2010-07-01
影响因子：
4.7
通讯作者：
Bhowmick, Neil
中科院分区：
文献类型：
--
作者：
Ge, Lin;Meng, Wenxia;Bhowmick, Neil
常见的口腔疾病和口腔癌一样，都具有场致癌变或场效应的特点。现场癌变是头颈部肿瘤的一种临床现象，其特征是直接癌细胞的邻近细胞发生表型和遗传改变。上皮细胞的现场癌变是目前癌症生物学中广泛接受的模型，作为癌症进展的表现。近年来，肿瘤微环境的变化引起了人们的广泛关注。肿瘤微环境的改变和上皮细胞癌变的概念是否有联系？鉴于间质在上皮细胞发育中的重要性和癌相关间质的证据，我们提出了间质是否不仅与上皮细胞的肿瘤性变化相互作用，而且还有助于实地癌变的问题。事实上，有一篇前瞻性的论文指出，伤口愈合可以影响癌变的复发。也就是说，愈合创面的微环境决定了野战癌变的预后。基于已发表的文献和我们自己的工作，我们假设了一个新的模型，现场癌变的肿瘤微环境的共同演变为重点。我们认为，在治疗具有野外癌变特征的疾病时，不能忽视微环境。(C)2010爱思唯尔有限公司版权所有。
The common oral diseases as well as oral cancer have the characteristic of field cancerization or field effect. Field cancerization, characterized by phenotypic and genetic changes in the neighboring cells of the frank cancer cells, is a clinical phenomenon first found in head and neck cancers. Field cancerization of the epithelia is currently a widely-accepted model in cancer biology as a manifestation of cancer progression. The concomitant changes in the tumor microenvironment have drawn more attention recently. Could the changes in the tumor microenvironment and the epithelial field cancerization concepts be linked? In view of the importance of stroma in the development of epithelium and evidence in carcinoma-associated stroma, we propose the question if stroma not only reciprocates the neoplastic changes of the epithelia, but also contributes to field cancerization. Actually one perspective paper pointed out that healing wound can influence the recurrence of field cancerization. In another words, the microenvironment of healing wound determines the prognosis of field cancerization. Based on the literatures published and our own work, we hypothesize a new model of field cancerization focusing on the co-evolution of the tumor microenvironment. We suggest that the microenvironment cannot be neglected when treating diseases with characteristics of field cancerization. (C) 2010 Elsevier Ltd. All rights reserved.