The neural bases of uninstructed negative emotion modulation.
The neural bases of uninstructed negative emotion modulation.
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DOI：
10.1093/scan/nsu016
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发表时间：
2015
影响因子：
4.2
通讯作者：
J. Silvers;T. Wager;J. Weber;K. Ochsner
中科院分区：
文献类型：
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作者：
J. Silvers;T. Wager;J. Weber;K. Ochsner
尽管许多神经成像研究已经研究了当个体被指示调节情绪时会发生什么，但我们在日常生活中很少收到这样的指示。本研究试图通过检查对消极刺激“自然反应”时的神经反应，以及在对消极刺激进行有指导的重新评价时进行比较，来检查消极影响的非指示调节的基础。进行了两项分析，以确定在自然反应时，消极影响的可变性与神经反应的关系。首先，在一项参与者内部分析中，在给定的试验中，较低水平的自我报告的负面情绪与背外侧和背内侧前额叶皮层（PFC）的激活有关，PFC是在指示重新评估期间也活跃的大脑区域，而较高水平的负面情绪与杏仁核的激活有关，杏仁核对负面刺激的反应总体上比中性刺激更强烈。其次，在参与者之间的分析中，较低水平的平均自我报告的负面情绪与腹内侧PFC的招募有关。这些结果表明，情绪的非指导调节涉及两种调节过程的组合，其中即时调节取决于支持重新评估的前额叶区域，而调节取决于腹内侧PFC的个体差异，这一区域涉及恐惧消退。
Although numerous neuroimaging studies have examined what happens when individuals are instructed to regulate their emotions, we rarely receive such instruction in everyday life. This study sought to examine what underlies uninstructed modulation of negative affect by examining neural responses when 'responding naturally' to negative stimuli-and for comparison-during instructed reappraisal of negative stimuli as well. Two analyses were conducted to identify how variability in negative affect related to neural responses when responding naturally. First, in a within-participant analysis, lower levels of self-reported negative affect on a given trial were associated with recruitment of dorsolateral and dorsomedial prefrontal cortex (PFC)-brain regions also active during instructed reappraisal-whereas higher levels of negative affect were associated with recruitment of the amygdala-a region that responded more strongly overall to negative than neutral stimuli. Second, in a between-participant analysis, lower levels of average self-reported negative affect were associated with recruitment of ventromedial PFC. These results suggest that uninstructed modulation of emotion involves a combination of two types of regulatory processes, with moment-to-moment modulation depending on prefrontal regions that support reappraisal and individual differences in modulation depending on ventromedial PFC, a region involved in fear extinction.