Role of Ventromedial hypothalamus in high fat diet induced obesity in male rats: association with lipid profile, thyroid profile and insulin resistance.
Role of Ventromedial hypothalamus in high fat diet induced obesity in male rats: association with lipid profile, thyroid profile and insulin resistance.
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DOI：
10.5214/ans.0972.7531.210306
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发表时间：
2014-07
影响因子：
1.5
通讯作者：
Pal P
中科院分区：
文献类型：
--
作者：
Gaur A;Pal GK;Ananthanarayanan PH;Pal P
腹内侧下丘脑（VMH）在食物摄取、肥胖和能量平衡中起重要作用。有报告称，能量平衡方面存在性别差异，男性更容易患心脏病。身体代谢受我们饮食的影响很大，一些血液参数如血糖、胰岛素、血脂和甲状腺状况描绘了身体能量稳态的画面。本研究旨在探讨VMH在高脂饮食诱导的雄性Wistar大鼠肥胖中的作用及其与胰岛素、血糖、甲状腺和血脂的关系。雄性大鼠（n = 12）给予HFD 10周以诱导肥胖。在获得摄食量、体重、葡萄糖、胰岛素、甲状腺和脂质特征的基础记录后，将动物分为对照组和实验组（每组n = 6只雄性）。实验组大鼠进行电解消融VMH，而对照组大鼠进行假损伤。在4周结束时进行损伤后记录。两组大鼠在HFD时间表后的摄食量和体重增加均更大。VMH损伤后，摄食量进一步增加，仅实验组增加。实验组血糖、胰岛素、HOMA-IR、总胆固醇（TC）、甘油三酯（TG）均较损伤前显著升高（P<0.001）。10周的HFD导致肥胖。VMH似乎可以防止高脂饮食后影响雄性大鼠能量稳态的胰岛素抵抗和高胆固醇血症的发展。
Ventromedial hypothalamus (VMH) plays a major role in food intake, obesity and energy homeostasis. There is a report of gender difference in energy balance with increased vulnerability of males to cardiac disease. Body metabolism is greatly influenced by the diet we eat and some of the blood parameters like plasma glucose, insulin, lipid profile and thyroid profile depict a picture of energy homeostasis of the body. The present study was conducted to assess the effect of VMH in high fat diet (HFD) induced obesity and its link with insulin, glucose, thyroid and lipid profile of male Wistar rats. The male rats (n = 12) were given HFD for a period of 10 weeks to induce obesity. After obtaining a basal recording of food intake, body weight, glucose, insulin, thyroid and lipid profile, animals were divided into control and experimental group (n = 6 male in each). Experimental rats underwent electrolytic ablation of VMH whereas control rats underwent sham lesion. A post-lesion recording was taken at the end of four weeks. The rats had a greater food intake and more body weight gain after HFD schedule in both the groups. After VMH lesion, food intake increased further, only in experimental group. Plasma glucose, Insulin, HOMA - IR, total cholesterol (TC) and triglycerides (TG) were significantly increased compared to the pre-lesion values in experimental group (P<0.001). Ten week of HFD resulted in obesity. VMH appears to prevent the development of insulin resistance and hypercholesterolemia which influences the energy homeostasis in male rats after high fat diet.