Short term wear of high Dk soft contact lenses does not alter corneal epithelial cell size or viability
Short term wear of high Dk soft contact lenses does not alter corneal epithelial cell size or viability
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短期佩戴高 Dk 软性隐形眼镜不会改变角膜上皮细胞的大小或活力
DOI：
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发表时间：
2001
影响因子：
4.1
通讯作者：
L. Keay
中科院分区：
文献类型：
--
作者：
F. Stapleton;S. Kasses;S. Bolis;L. Keay
背景/目的电流隐形眼镜(CLS)在长时间佩戴时会引起角膜上皮细胞的改变。本研究的目的是评估短期(3个月)佩戴高透氧性CLS后角膜上皮细胞形态和生理的变化，并与一次性CLS进行比较。方法受试者为穿戴高透氧性CLS者(n=11，佩戴CLS 30晚)、一次性CLS使用者(n=6，佩戴CLS 6晚)和未佩戴CLS者(n=20)。平均CL磨损经验为3个月。用角膜细胞学方法收集角膜上皮细胞，用吖啶橙和溴化乙锭进行染色。测定上皮细胞大小和存活率。结果回收的上皮细胞大部分为死活细胞(71%)，平均最大细胞直径为38(SD 8)μm，与未磨损(39(7)μm)和高透氧性(37(10)μm，p=0.0049)相比，一次性CLS的细胞大小(42(7)μm)明显增大。两组间细胞存活率无差异。结论一次性CLS长时间佩戴3个月后，角膜上皮细胞直径增加8%。高透氧性CLS佩戴3个月后获得的细胞与非CL佩戴者的细胞无明显区别。
BACKGROUND/AIMS Current contact lenses (CLs) when worn on an extended wear basis cause corneal epithelial alterations. The aim of this study was to evaluate changes in corneal epithelial cell morphology and physiology following short term (3 months) wear of highly oxygen permeable CLs and to compare this with disposable CLs. METHODS Subjects were wearers of highly oxygen permeable CLs (n=11, wearing CLs on a 30 night schedule), disposable CL users (n=6, wearing CLs on a 6 night schedule), and non-CL wearers (n=20). Mean CL wear experience was 3 months. Epithelial cells were harvested using corneal cytology and were stained using acridine orange and ethidium bromide. Epithelial cell size and viability were determined. RESULTS The majority of epithelial cells recovered were non-viable (71%), and the mean longest cell diameter was 38 (SD 8) μm. Disposable CLs caused an increase in cell size (42 (7) μm) compared with both non-wear (39 (7) μm, p=0.01) and wear of highly oxygen permeable CLs (37 (10) μm, p=0.0049). There was no difference in cell viability between groups. CONCLUSIONS Extended wear of disposable CLs caused an 8% increase in cell diameter in harvested corneal epithelial cells following 3 months of CL wear. Cells harvested following 3 months' wear of highly oxygen permeable CLs were indistinguishable from those recovered from non-CL wearers.
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长戴亲水性隐形眼镜对人角膜上皮的影响。
影响因子：
4.2
作者：
Lemp,MA;Gold,JB
通讯作者：
Gold,JB
影响因子：
4.4
作者：
H. Ren;G. Wilson
通讯作者：
H. Ren;G. Wilson
软镜片长期佩戴会影响上皮屏障功能。
DOI：
10.1016/s0161-6420(98)91237-4
发表时间：
1998
期刊：
Ophthalmology.
影响因子：
--
作者：
McNamara,NA;Polse,KA;Fukunaga,SA;Maebori,JS;Suzuki,RM
通讯作者：
Suzuki,RM
影响因子：
2
作者：
Wilson,G
通讯作者：
Wilson,G