CLINICAL, LABORATORY, AND IMMUNOLOGICAL STUDIES OF A FAMILY WITH A HIGH PREVALENCE OF GENERALIZED PREPUBERTAL AND JUVENILE PERIODONTITIS
CLINICAL, LABORATORY, AND IMMUNOLOGICAL STUDIES OF A FAMILY WITH A HIGH PREVALENCE OF GENERALIZED PREPUBERTAL AND JUVENILE PERIODONTITIS
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DOI：
10.1902/jop.1992.63.5.457
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发表时间：
1992-05-01
影响因子：
4.3
通讯作者：
LOPEZ, NJ
中科院分区：
文献类型：
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作者：
LOPEZ, NJ
对一个有局限性青少年牙周炎(LJP)和全身性青春期前牙周炎(GPP)高患病率的血缘家庭进行了为期7年半的研究。父母患有成人牙周炎，而两个女儿，年龄分别为13岁和15岁，患有LJP。此外，另外两个14岁和10岁的女儿以及一个9岁的儿子也受到了GPP的影响。剩下的两个兄弟姐妹没有受到影响。对所有家庭成员进行了临床和放射检查，并评估了血液中性粒细胞的趋化能力。对GPP患者进行实验室检查、免疫学检查和中性粒细胞功能评估。对2名GPP患者和母亲进行了微生物培养。母亲、2名LJP患者和1名未受影响的兄弟姐妹中性粒细胞趋化性降低。其他家庭成员，包括3名GPP患者，中性粒细胞趋化性正常。GPP患者没有任何系统性疾病，也没有检测到免疫功能主要缺陷的证据。LJP患者成功地接受了根面平整、龈下刮除和四环素治疗。3例GPP患者强化牙周治疗联合全身应用抗生素未能有效阻止牙周组织破坏。结果表明，GPP的潜在原因并不总是与白细胞功能障碍有关。伴生放线杆菌是2例GPP患者龈下菌群中最常见的病原菌，推测其可能在GPP的病原学中起关键作用。
A STUDY OF A CONSANGUINEOUS FAMILY with a high prevalence of localized juvenile periodontitis (LJP) and generalized prepubertal periodontitis (GPP) was done over a 7-and-a-half year period. The parents had adult periodontitis, while 2 daughters, aged 13 and 15, had LJP. Furthermore, 2 other daughters, ages 14 and 10, and a son, aged 9, were affected by GPP. Two remaining siblings were not affected. Clinical and radiographic examinations on all family members were done, and chemotaxis for blood neutrophils was assessed. Laboratory tests, immunological examinations, and evaluation for neutrophil functions were done on the GPP patients. Microbiological cultures were performed on 2 of the GPP patients, as well as in the mother. The mother, the 2 LJP patients, and 1 of the unaffected siblings had depressed PMN chemotaxis. The other family members, including the 3 GPP patients, had normal PMN chemotaxis. GPP patients did not have any systemic disease, and evidence of major defects in the immunological functions was not detected. LJP patients were successfully treated with root planing, subgingival curettage, and tetracycline therapy. Intensive periodontal therapy, combined with systemic administration of antibiotics, was not effective in halting periodontal tissue destruction in the 3 GPP patients. Results indicate that the underlying cause of GPP is not always related to leukocyte dysfunction. Since Actinobacillus actinomycetemcomitans was the most frequent pathogen found in subgingival microflora of 2 of the GPP patients, it is assumed that it may play a key role in the etiology of GPP.