Oral steroid treatment of sudden sensorineural hearing loss: A ten year retrospective analysis
Oral steroid treatment of sudden sensorineural hearing loss: A ten year retrospective analysis
复制标题
DOI：
10.1097/00129492-200309000-00006
复制
发表时间：
2003-09-01
影响因子：
2.1
通讯作者：
Rauch, SD
中科院分区：
文献类型：
--
作者：
Chen, CY;Halpin, C;Rauch, SD
目的：描述10年来突发性感音神经性听力损失的经验，并比较口服皮质类固醇治疗和不治疗的结果。研究设计：回顾性分析病历。设置：大型专科医院，耳鼻喉科。患者：突然发作的患者（72小时）单侧感音神经性听力损失，无梅尼埃病、声损伤、耳蜗后疾病和其他可指定疾病的证据。大多数患者接受标准疗程的口服皮质类固醇（泼尼松60 mg和逐渐减少）。主要结果测量：使用标准测听法测量听力敏感度的恢复，并报告为纯音平均值的变化。单词识别分数也进行了分析。结果：当严重到深刻的情况下进行分析，一个显着的改善（p <0.01），纯音平均被认为是与未治疗的类固醇治疗的情况下。当包括较轻的病例时，统计地板效应阻止了这些群体的区分。单词识别分数显着提高（p <0.05），在治疗group.Conclusions：类固醇药物的应用显着改善严重突发性感音神经性听力损失的情况下恢复的结果。
Objective: To describe ten years of experience with Sudden Sensorineural Hearing Loss and compare the outcomes with and without treatment with oral corticosteroids.Study Design: Retrospective review of medical records.Setting: Large specialty hospital, Department of Otolaryngology.Patients: Patients presenting with sudden onset (72 hours) unilateral sensorineural hearing loss, with no evidence of Meniere's Disease, acoustic injury, retrocochlear disease, and other specifiable disorders.Interventions: The majority of patients received a standard course of oral corticosteroids (Prednisone 60mg and taper). A smaller group declined treatment.Main Outcome Measures: Recovery of hearing sensitivity was measured using standard audiometry and reported as change in Pure Tone Average. Word recognition scores were also analyzed.Results: When severe-to-profound cases are analyzed, a significant improvement (p < .01) in Pure Tone Average is seen in cases treated with steroids versus those untreated. When milder cases are included, a statistical floor effect prevents differentiation of these groups. Word recognition scores were significantly improved (p < .05) in the treated group.Conclusions: Application of steroid medication significantly improves the recovery outcomes in cases of Severe Sudden Sensorineural Hearing Loss.