Amygdala responsiveness to emotional words is modulated by subclinical anxiety and depression
Amygdala responsiveness to emotional words is modulated by subclinical anxiety and depression
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DOI：
10.1016/j.bbr.2012.05.036
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发表时间：
2012-08-01
影响因子：
2.7
通讯作者：
Zwanzger, Peter
中科院分区：
文献类型：
--
作者：
Laeger, Inga;Dobel, Christian;Zwanzger, Peter
几项神经影像学研究强调了杏仁核和前额叶脑结构（例如背外侧前额叶皮层[DLPFC]）对处理情绪刺激和情绪调节的重要性。许多研究使用视觉场景或面孔作为情绪诱导材料，有证据表明消极或积极的词语以同样的方式激活大脑处理情绪的区域。然而，到目前为止，还没有研究集中在焦虑或抑郁的亚临床措施对情绪词的神经加工的影响。因此，在这项fMRI研究中，我们调查了21名健康受试者的样本中情绪词汇与特质焦虑和抑郁的亚临床测量相关的大脑激活。我们还评估了亚临床焦虑和抑郁对消极（与中性）词阅读过程中杏仁核-前额叶耦合的影响。消极词和积极词都能激活杏仁核，消极词处理揭示了杏仁核活性与特质焦虑和亚临床抑郁得分之间的正相关。在消极词和中性词的阅读过程中，高特质焦虑者的左侧杏仁核和左侧DLPFC之间也表现出更强的功能耦合。这些结果表明，调制的负字处理亚临床抑郁症和焦虑症，以及可能的前额叶补偿过程中无意的情绪调节具有较高的特质焦虑。(C)2012爱思唯尔有限公司版权所有。
Several neuroimaging studies underlined the importance of the amygdala and prefrontal brain structures (e.g. dorsolateral prefrontal cortex [DLPFC]) for the processing of emotional stimuli and for emotion regulation. Many studies used visual scenes or faces as emotion-inducing material, and there is evidence that negative or positive words activate emotion-processing brain regions in the same way. However, no study so far focused on the influence of subclinical measures of anxiety or depression on the neural processing of emotional words. In this fMRI-study, we therefore investigated brain activation to emotional words in relation to subclinical measures of trait anxiety and depression in a sample of 21 healthy subjects. We also assessed effects of subclinical anxiety and depression on amygdala-prefrontal coupling during negative (versus neutral) word reading. Both negative and positive words activated the amygdala, and negative-word processing revealed a positive correlation between amygdala activity and scores of trait anxiety and subclinical depression. During negative versus neutral word reading, subjects with high trait anxiety also showed a stronger functional coupling between left amygdala and left DLPFC. These results suggest a modulation of negative-word processing by subclinical depression and anxiety, as well as possible prefrontal compensatory processes during unintentional emotion regulation in subjects with higher trait anxiety. (C) 2012 Elsevier B.V. All rights reserved.