CYCLOSPORINE - A REVIEW AND ITS SPECIFIC USE IN LIVER-TRANSPLANTATION
CYCLOSPORINE - A REVIEW AND ITS SPECIFIC USE IN LIVER-TRANSPLANTATION
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DOI：
10.1016/s0025-6196(12)65348-8
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发表时间：
1989-06-01
影响因子：
8.9
通讯作者：
DEGROEN, PC
中科院分区：
文献类型：
--
作者：
DEGROEN, PC
在过去的十年中，环孢菌素（一种免疫抑制剂）的治疗对于提高同种异体肝移植和肝移植后患者的生存率做出了重大贡献。目前，各大肝移植中心肝移植后1年生存率均在80%以上，而环孢素上市前约为60%。其主要免疫作用是抑制辅助 T 细胞产生和分泌淋巴因子。然而，环孢菌素的使用与许多副作用相关，其中最重要的是肾毒性、高血压、神经毒性、机会性感染和恶性病变。急性肾毒性、高血压和神经毒性通常可以通过减少环孢素的剂量来逆转。测量血液中环孢菌素浓度对于优化免疫抑制治疗和预防毒性至关重要。
During the past decade, treatment with cyclosporine, an immunosuppressive agent, has contributed substantially to enhanced allograft and patient survival after liver transplantation. Currently, the 1-year survival rate after liver transplantation is more than 80% in major liver transplantation centers, in contrast with approximately 60% before the availability of cyclosporine. Its predominant immunologic effect is inhibition of lymphokine production and secretion by helper T cells. The use of cyclosporine, however, is associated with numerous adverse effects, the most important of which are nephrotoxicity, hypertension, neurotoxicity, opportunistic infections, and malignant lesions. Acute nephrotoxicity, hypertension, and neurotoxicity usually can be reversed by decreasing the dose of cyclosporine. Measurement of cyclosporine concentrations in the blood is essential for optimization of immunosuppressive therapy and prevention of toxicity.