Behavioral effects of congenital ventromedial prefrontal cortex malformation
Behavioral effects of congenital ventromedial prefrontal cortex malformation
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DOI：
10.1186/1471-2377-11-151
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发表时间：
2011-12-02
期刊：
影响因子：
2.6
通讯作者：
Anderson, Steven W.
中科院分区：
文献类型：
--
作者：
Boes, Aaron D.;Grafft, Amanda Hornaday;Anderson, Steven W.
背景：先前尚未报道与腹内侧前额叶皮质（vmPFC）局灶性先天性畸形相关的详细行为特征。在这里，我们描述了一名 14 岁男孩 B.W.，他因左侧 vmPFC 局灶性皮质畸形而产生神经和精神后遗症。病例介绍：B.W. 的行为特征是通过对临床和个人记录的广泛审查、耐心以及行为和神经心理学测试来表征的。行为特征的一个核心特征是严重的反社会行为。他咄咄逼人、控制欲强、冷酷无情。符合精神病态的特征。其他问题包括：以自我为中心、冲动、多动、缺乏同理心、缺乏对权威的尊重、道德判断力受损、无法提前计划以及对挫折的承受力差。结论：vmPFC 对人类亲社会行为的发展有着深远的贡献。 B.W. 展示了该皮质区域的先天性损伤如何严重扰乱这一过程。
Background: A detailed behavioral profile associated with focal congenital malformation of the ventromedial prefrontal cortex (vmPFC) has not been reported previously. Here we describe a 14 year-old boy, B. W., with neurological and psychiatric sequelae stemming from focal cortical malformation of the left vmPFC.Case Presentation: B.W.'s behavior has been characterized through extensive review Patience of clinical and personal records along with behavioral and neuropsychological testing. A central feature of the behavioral profile is severe antisocial behavior. He is aggressive, manipulative, and callous; features consistent with psychopathy. Other problems include: egocentricity, impulsivity, hyperactivity, lack of empathy, lack of respect for authority, impaired moral judgment, an inability to plan ahead, and poor frustration tolerance.Conclusions: The vmPFC has a profound contribution to the development of human prosocial behavior. B. W. demonstrates how a congenital lesion to this cortical region severely disrupts this process.