TIME-DEPENDENT PHRENIC-NERVE RESPONSES TO CAROTID AFFERENT ACTIVATION - INTACT VS DECEREBELLATE RATS
TIME-DEPENDENT PHRENIC-NERVE RESPONSES TO CAROTID AFFERENT ACTIVATION - INTACT VS DECEREBELLATE RATS
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DOI：
10.1152/ajpregu.1993.265.4.r811
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发表时间：
1993-10-01
影响因子：
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通讯作者：
MCCRIMMON, DR
中科院分区：
文献类型：
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作者：
HAYASHI, F;COLES, SK;MCCRIMMON, DR
目的是确定1）麻醉大鼠对颈动脉化学感受器输入的呼吸反应和2）小脑蚓部是否在这些反应中发挥作用。颈动脉窦神经刺激（20 Hz）与5个2分钟的列车，每个约3分钟的间隔。在刺激过程中，呼吸频率（f），综合膈神经活动（积分Phr）的峰值幅度，和他们的产品（f X积分Phr）立即增加。随着刺激的继续，积分Phr逐渐增加到一个平台[短期增强（STP）]，但f和f X积分Phr下降[短期抑制（STD）]到一个值仍然高于控制。刺激终止后，积分Phr逐渐降低，但仍高于对照组; f和f x f积分Phr短暂降低至基线以下。最终刺激后，积分Phr保持高于对照至少30分钟[长期易化（LTF）]。重复5分钟的等二氧化碳缺氧发作也引起STP，STD和LTF。椎骨切除术降低了CO2-呼吸暂停阈值并消除了LTF。总之，大鼠颈动脉化学感受器激活可引起与猫相似的STP和LTF，蚓部可能在LTF中起作用。观察到新的反应STD。
The objectives were to determine 1) respiratory responses to carotid chemoreceptor inputs in anesthetized rats and 2) whether the cerebellar vermis plays a role in these responses. A carotid sinus nerve was stimulated (20 Hz) with five 2-min trains, each separated by approximately 3 min. During stimulation, respiratory frequency (f), peak amplitude of integrated phrenic nerve activity (integral Phr), and their product (f X integral Phr) immediately increased. As stimulation continued, integral Phr progressively increased to a plateau [short-term potentiation (STP)], but f and f X integral Phr decreased [short-term depression (STD)] to a value still above control. Upon stimulus termination, integral Phr progressively decreased but remained above control; f and f x f integral Phr transiently decreased below baseline. After the final stimulation, integral Phr remained above control for at least 30 min [long-term facilitation (LTF)]. Repeated 5-min episodes of isocapnic hypoxia also elicited STP, STD, and LTF. Vermalectomy lowered the CO2-apneic threshold and eliminated LTF. In conclusion, carotid chemoreceptor activation in rats elicits STP and LTF similar to that in cats; the vermis may play a role in LTF. A new response, STD, was observed.