Implications of salivary protein binding to commensal and pathogenic bacteria.
Implications of salivary protein binding to commensal and pathogenic bacteria.
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DOI：
10.1016/j.job.2013.06.004
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发表时间：
2013-11-01
影响因子：
2.4
通讯作者：
Scannapieco FA
中科院分区：
文献类型：
--
作者：
Heo SM;Ruhl S;Scannapieco FA
唾液蛋白的一个重要功能是与进入口腔的微生物相互作用。对于一些微生物来说，这些相互作用促进了微生物的定植。对另一些人来说，这些相互作用是有害的，并导致口腔微生物的消除。本文综述了最近关于唾液蛋白与两种模式细菌相互作用的研究；共生物种戈登链球菌和兼性病原体金黄色葡萄球菌。这些生物选择性地与多种唾液蛋白相互作用，影响细菌粘附表面、逃避宿主防御、细菌营养和代谢以及基因表达等重要功能。
An important function of salivary proteins is to interact with microorganisms that enter the oral cavity. For some microbes, these interactions promote microbial colonization. For others, these interactions are deleterious and result in the elimination of the microbe from the mouth, This paper reviews recent studies of the interaction of salivary proteins with two model bacteria; the commensal species Streptococcus gordonii, and the facultative pathogen Staphylococcus aureus. These organisms selectively interact with a variety of salivary proteins to influence important functions such as bacterial adhesion to surfaces, evasion of host defense, bacterial nutrition and metabolism and gene expression.