ADAPTIVE ASSIGNMENT VERSUS BALANCED RANDOMIZATION IN CLINICAL-TRIALS - A DECISION-ANALYSIS
ADAPTIVE ASSIGNMENT VERSUS BALANCED RANDOMIZATION IN CLINICAL-TRIALS - A DECISION-ANALYSIS
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DOI：
10.1002/sim.4780140302
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发表时间：
1995-02-15
影响因子：
2
通讯作者：
EICK, SG
中科院分区：
文献类型：
--
作者：
BERRY, DA;EICK, SG
在一项涉及两种治疗的临床试验中，我们比较了平衡随机化和四种适应性治疗分配程序。目标是尽可能有效地治疗试验内外的更多患者。当所讨论的疾病至少是中等常见的时候，随机化是决策问题的令人满意的解决方案。适应性手术更难使用，但当相当大比例的所有患有这种疾病的患者纳入试验时，可能会在临床研究中发挥作用。
We compare balanced randomization with four adaptive treatment allocation procedures in a clinical trial involving two treatments. The objective is to treat as many patients in and out of the trial as effectively as possible. Randomization is a satisfactory solution to the decision problem when the disease in question is at Least moderately common. Adaptive procedures are more difficult to use, but might play a role in clinical research when a substantial proportion of all patients with the disease are included in the trial.