Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms
Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms
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DOI：
10.1111/j.1469-7793.1999.0611v.x
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发表时间：
1999-04-15
影响因子：
5.5
通讯作者：
Czeisler, CA
中科院分区：
文献类型：
--
作者：
Dijk, DJ;Duffy, JF;Czeisler, CA
1.昼夜节律计时系统与人类睡眠结构、时间和巩固的年龄相关变化有关。我们调查了13名老年男性和女性以及11名年轻男性的睡眠昼夜节律调节，通过强迫剥夺多导睡眠图记录的睡眠事件（总共482次，每次9小时20分钟）以及血浆褪黑激素和核心体温的昼夜节律。老年人的第四阶段睡眠减少。快速眼动（REM）睡眠的总体水平不受年龄的显著影响。当睡眠与褪黑激素节律一致时，老年人的睡眠时间较短。快速眼动睡眠在睡眠的第一个四分之一增加，而老年人在睡眠过程中快速眼动睡眠的增加减少。两个年龄组的睡眠倾向与体温和血浆褪黑激素的昼夜节律有关。睡眠潜伏期在褪黑激素分泌开始前最长，睡眠潜伏期在温度最低点附近较短。在老年人的睡眠中，睡眠时间较长，接近褪黑激素节律的峰值。在老年人中，睡眠持续时间在所有昼夜节律阶段都减少，睡眠巩固在睡眠过程中更快地恶化，特别是当睡眠事件的后半部分发生在褪黑激素节律的波峰之后时。这些数据表明，老年人睡眠巩固的年龄相关性下降和对昼夜节律相位失调的敏感性增加。这些变化，以及相关的从睡眠中醒来的倾向的内部相位提前，似乎与睡眠的稳态驱动力减少和促进清晨睡眠的昼夜节律信号强度降低之间的相互作用有关。
1. The circadian timing system has been implicated in age-related changes in sleep structure, timing and consolidation in humans.2. We investigated the circadian regulation of sleep in 13 older men and women and 11 young men by forced desynchrony of polysomnographically recorded sleep episodes (total, 482; 9 h 20 min each) and the circadian rhythms of plasma melatonin and core body temperature.3. Stage 4 sleep was reduced in older people. Overall levels of rapid eye movement (REM) sleep were not significantly affected by age. The latencies to REM sleep were shorter in older people when sleep coincided with the melatonin rhythm. REM sleep was increased in the first quarter of the sleep episode and the increase of REM sleep in the course of sleep was diminished in older people.4. Sleep propensity co-varied with the circadian rhythms of body temperature and plasma melatonin in both age groups. Sleep latencies were longest just before the onset of melatonin secretion and short sleep latencies were observed close to the temperature nadir. In older people sleep latencies were longer close to the crest of the melatonin rhythm.5. In older people sleep duration was reduced at all circadian phases and sleep consolidation deteriorated more rapidly during the course of sleep, especially when the second half of the sleep episode occurred after the crest of the melatonin rhythm.6. The data demonstrate age-related decrements in sleep consolidation and increased susceptibility to circadian phase misalignment in older people. These changes, and the associated internal phase advance of the propensity to awaken from sleep, appear to be related to the interaction between a reduction in the homeostatic drive for sleep and a reduced strength of the circadian signal promoting sleep in the early morning.