Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV
Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV
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DOI：
10.1128/iai.01860-05
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发表时间：
2006-08-01
影响因子：
3.1
通讯作者：
Schneewind, Olaf
中科院分区：
文献类型：
--
作者：
DeBord, Kristin L.;Anderson, Deborah M.;Schneewind, Olaf
与鼠疫耶尔森氏菌LcrV相反，重组V10（rV10）变体（缺少残基271至300）不抑制免疫细胞释放促炎细胞因子。用rV10免疫产生了强有力的抗体应答，保护小鼠免受腺鼠疫和肺鼠疫的侵害，这表明rV10可以作为改进的鼠疫疫苗。
In contrast to Yersinia pestis LcrV, the recombinant V10 (rV10) variant (lacking residues 271 to 300) does not suppress the release of proinflammatory cytokines by immune cells. Immunization with rV10 generates robust antibody responses that protect mice against bubonic plague and pneumonic plague, suggesting that rV10 may serve as an improved plague vaccine.