Genetic African Ancestry and Markers of Mineral Metabolism in CKD
Genetic African Ancestry and Markers of Mineral Metabolism in CKD
复制标题
DOI：
10.2215/cjn.08020715
复制
发表时间：
2016-04-01
影响因子：
9.8
通讯作者：
Wolf, Myles
中科院分区：
文献类型：
--
作者：
Gutierrez, Orlando M.;Parsa, Afshin;Wolf, Myles
背景和目的非裔美国人CKD患者的矿物质代谢紊乱比欧裔美国人CKD患者更常见。以往的研究主要集中在自我报告的种族之间矿物质代谢的差异上，这使得与生物因素相比，环境因素的重要性很难界定。设计、设置、参与者和测量在一项对3013名慢性肾功能不全队列研究参与者的横断面分析中，我们比较了矿物质代谢的标志物（磷，钙，碱性磷酸酶，甲状旁腺激素，成纤维细胞生长因子23，尿钙和磷排泄）在欧洲裔美国人与非洲裔美国人和单独，跨四分位数的遗传非洲血统的非洲裔美国人（n=1490）。非裔美国人血磷、碱性磷酸酶、成纤维细胞生长因子23和甲状旁腺激素浓度较高，24小时尿钙和磷排泄量较低，基线时尿钙和磷排泄分数较低（P
Background and objectives Disorders of mineral metabolism are more common in African Americans with CKD than in European Americans with CKD. Previous studies have focused on the differences in mineral metabolism by self-reported race, making it difficult to delineate the importance of environmental compared with biologic factors.Design, setting, participants, & measurements In a cross-sectional analysis of 3013 participants of the Chronic Renal Insufficiency Cohort study with complete data, we compared markers of mineral metabolism (phosphorus, calcium, alkaline phosphatase, parathyroid hormone, fibroblast growth factor 23, and urine calcium and phosphorus excretion) in European Americans versus African Americans and separately, across quartiles of genetic African ancestry in African Americans (n=1490).Results Compared with European Americans, African Americans had higher blood concentrations of phosphorus, alkaline phosphatase, fibroblast growth factor 23, and parathyroid hormone, lower 24-hour urinary excretion of calcium and phosphorus, and lower urinary fractional excretion of calcium and phosphorus at baseline (P