Severity of cardiovascular disease in postmenopausal women:: associations with common estrogen receptor α polymorphic variants
Severity of cardiovascular disease in postmenopausal women:: associations with common estrogen receptor α polymorphic variants
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DOI：
10.1530/eje-06-0685
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发表时间：
2007-04-01
影响因子：
5.8
通讯作者：
Sarika, H-L
中科院分区：
文献类型：
--
作者：
Alevizaki, M.;Saltiki, K.;Sarika, H-L
目的：雌激素作用受损是冠心病（CAD）的危险因素。CAD与雌激素受体α（ER α）多态性的关联，可能影响对雌激素的敏感性，已报告男性;关于女性的数据是不确定的。方法：在157名妇女（年龄45-88岁）中研究了ER α在c.454-397 T > C（PvuII）和c.454-351 A > G（XbaI）位点的多态性。结果：TT、TC和CC基因型（PvuII）与CAD的严重程度显著相关（P=0.008）; XbaI基因多态性与CAD的严重程度相关（P =0.021）。这些关联独立于CAD的其他风险因素。C等位基因纯合子的妇女甘油三酯和胰岛素水平显著较高，她们更常属于生育次数少的群体（n
Objective: Impaired estrogen action is a risk factor for coronary artery disease (CAD). Associations of CAD with estrogen receptor alpha (ER alpha) polymorphisms, which may influence sensitivity to estrogen, have been reported for men; the data concerning women are not conclusive. We investigated the association of common ER(x polymorphisms with the severity of CAD and with metabolic and reproductive factors in postmenopausal women undergoing coronary angiography.Methods: ER alpha polymorphisms at positions c.454-397 T > C (PvuII) and c.454-351 A > G (XbaI) were studied in 157 women (age 45-88 years). The severity of CAD was assessed by the number of arteries with > 50% stenosis in the angiography.Results: There was a significant association between the TT, TC, and CC genotypes (PvuII) and the severity of CAD (P=0.008); similar results were obtained for the XbaI polymorphism (P=0.021). These associations were independent of other risk factors for CAD. Women homozygous for the C allele had significantly higher triglyceride and insulin levels; they belonged more frequently to the group with a low number of births (n