NFATc1 and NFATc2 together control both T and B cell activation and differentiation
NFATc1 and NFATc2 together control both T and B cell activation and differentiation
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DOI：
10.1016/s1074-7613(01)00085-1
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发表时间：
2001-01-01
期刊：
影响因子：
32.4
通讯作者：
Glimcher, LH
中科院分区：
文献类型：
--
作者：
Peng, SL;Gerth, AJ;Glimcher, LH
NFAT转录因子在免疫应答过程中的基因转录中起关键作用。为了进一步研究两个最突出的NFAT家族成员，NFATc1和NFATc2，我们产生了携带淋巴系统缺乏两者的小鼠。双重缺陷的T细胞显示细胞表面标志物的活化，但显着缺乏的发展中的多种效应功能，包括Th细胞因子的生产，表面效应分子的表达，和细胞溶解活性。然而，双缺陷B细胞过度活化，如血清IgG 1和IgE极高以及浆细胞扩增和终末器官浸润所证明。因此，在T细胞中，NFATc 1和NFATc 2是炎症反应性的调节者，但是是效应分化所需的，而在B细胞中，NFAT调节正常的稳态和分化。
NFAT transcription factors play critical roles in gene transcription during immune responses. To investigate further the two most prominent NFAT family members, NFATc1 and NFATc2, we generated mice bearing lymphoid systems devoid of both. Doubly deficient T cells displayed cell surface markers of activation yet were significantly deficient in the development of multiple effector functions, including Th cytokine production, surface effector molecule expression, and cytolytic activity. Nevertheless, doubly deficient B cells were hyperactivated, as evidenced by extremely elevated serum IgG1 and IgE, as well as plasma cell expansion and infiltration of end organs. Thus, in T cells, NFATc1 and NFATc2 are dispensable for inflammatory reactivity but are required for effector differentiation, while in B cells, NFATs regulate both normal homeostasis and differentiation.