CRANIOSYNOSTOSIS IN HYPER-IGE-SYNDROME
CRANIOSYNOSTOSIS IN HYPER-IGE-SYNDROME
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DOI：
10.1007/bf00441793
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发表时间：
1985-01-01
影响因子：
3.6
通讯作者：
HITZIG, WH
中科院分区：
文献类型：
--
作者：
HOGER, PH;BOLTSHAUSER, E;HITZIG, WH
本文报告一位九岁男童，患有高免疫球蛋白E症候群（HIE）及颅缝早闭症。矢状缝和矢状缝过早融合导致舟状头畸形。观察到部分视神经萎缩，无颅内压升高的临床体征。这是第四个报告的情况下，颅缝早闭的缺氧缺血性脑病。骨质疏松等骨异常是新生儿缺氧缺血性脑病的常见表现。除了它们的临床影响外，它们可能与HIE发病机制中涉及的因素有关，例如组织中的趋化性或单核细胞分化受损。
A 9-year-old boy with hyperimmunoglobulin-E-syndrome (HIE) and craniosynostosis is reported. Premature fusion of the sagittal and lambdoid suture led to scaphocephaly. A partial optic atrophy without clinical signs of raised intracranial pressure was observed. This is the fourth reported case of craniosynostosis in HIE. Bone anomalies like osteoporosis are frequent findings in HIE. Apart from their clinical impact they could be related to factors involved in the pathogenesis of HIE, such as impairment of chemotaxis in tissues or monocyte differentiation.