A randomized prospective study of the metabolic effects of four low-estrogen oral contraceptives.
A randomized prospective study of the metabolic effects of four low-estrogen oral contraceptives.
复制标题
四种低雌激素口服避孕药代谢影响的随机前瞻性研究。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
Briggs Mh
中科院分区：
文献类型：
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作者：
Briggs Mh
Healthy nonsmoking normotensive well-motivated young women were assigned at random to 1 of 4 different commercial low-estrogen oral contraceptives (OCs). Measurements of biochemical parameters were made on 2 blood specimens collected from fasting subjects late in the pretreatment cycle then again late in each treatment cycle for 12 months. All the women assigned to 1 product (0.5 mg norethindrone + 35 mcg ethinyl estradiol) dropped out of the study before the end of the 5th cycle but discontinuations with the other 3 products were few. Though the numbers of subjects were small the groups were closely matched and most of the metabolic differences were statistically significant. Products containing ethynodiol diacetate and norethindrone were associated with increases in serum total cholesterol and triglycerides but decreases in high-density-lipoprotein-cholesterol. In contrast the levonorgestrel-containing preparation produced significantly less of an effect on these tests. A similar pattern was seen with a range of blood coagulation and fibrinolytic factors. Minimal alterations were seen with the levonorgestrel preparation whereas those containing norethindrone or ethynodiol diacetate showed marked increases in factors 1 7 8 and 10 and plasminogen associated with a decrease in antithrombin 3. Differences in the metabolic impact of the various commercially available low-estrogen preparations combined with their effects on intermenstrual bleeding allow a choice of the progestogen component most suitable for general use. (authors)
