Early determinants of obesity: genetic, epigenetic, and in utero influences.
Early determinants of obesity: genetic, epigenetic, and in utero influences.
复制标题
DOI：
10.1155/2012/463850
复制
发表时间：
2012
影响因子：
2.1
通讯作者：
McCaffery J
中科院分区：
文献类型：
--
作者：
Rhee KE;Phelan S;McCaffery J
有一个新兴的研究机构表明，基因、表观遗传学和宫内环境可以影响儿童是否肥胖。虽然某些基因已经被发现会增加肥胖的风险，但其他因素也会影响这种风险，例如妊娠期体重增加过多、妊娠期糖尿病和吸烟。了解这些影响有助于告诉我们，如果我们要降低肥胖率，哪些行为和暴露应该成为目标。通过帮助父母和年幼的孩子在关键时期改变某些行为和暴露，我们可能能够改变或改变一个人的遗传倾向。然而，还需要进一步的研究来确定哪些努力在降低肥胖率方面是有效的，并开发新的预防方法。在这篇文章中，我们将讨论基因、表观遗传学和宫内影响如何影响肥胖的发展。然后，我们将讨论目前改变这些影响的努力，并为这项工作提出未来的方向。
There is an emerging body of work indicating that genes, epigenetics, and the in utero environment can impact whether or not a child is obese. While certain genes have been identified that increase one's risk for becoming obese, other factors such as excess gestational weight gain, gestational diabetes mellitus, and smoking can also influence this risk. Understanding these influences can help to inform which behaviors and exposures should be targeted if we are to decrease the prevalence of obesity. By helping parents and young children change certain behaviors and exposures during critical time periods, we may be able to alter or modify one's genetic predisposition. However, further research is needed to determine which efforts are effective at decreasing the incidence of obesity and to develop new methods of prevention. In this paper, we will discuss how genes, epigenetics, and in utero influences affect the development of obesity. We will then discuss current efforts to alter these influences and suggest future directions for this work.