A functional magnetic resonance imaging study of tic suppression in Tourette syndrome
A functional magnetic resonance imaging study of tic suppression in Tourette syndrome
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DOI：
10.1001/archpsyc.55.4.326
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发表时间：
1998-04-01
影响因子：
--
通讯作者：
Gore, JC
中科院分区：
文献类型：
--
作者：
Peterson, BS;Skudlarski, P;Gore, JC
背景：在广泛的神经精神障碍中，无法抑制不想要的行为和冲动会导致功能障碍。抽动抽动综合征中一种潜在的重要脉冲控制模式是意向性抽动抑制。方法：应用功能磁共振成像技术对22例成人抽动抽动综合征患者进行抽动抑制研究。将在自愿抽动抑制期间获得的图像与当受试者允许自发地表达他们的领带时获得的图像进行比较。图像中信号变化的大小与抽动症状的严重程度相关。结论：在基底节和丘脑以及被认为有助于完成注意力要求任务的解剖连接的皮质区域，信号强度发生了显著变化。基底节和丘脑的局部信号改变程度与抽动症状的严重程度呈负相关。这些发现表明，TIES的发病机制涉及皮质下神经回路中神经元活动的调节受损。
Background: The inability to inhibit unwanted behaviors and impulses produces functional debility in a broad range of neuropsychiatric disorders. A potentially important model of impulse control is volitional tic suppression in Tourette syndrome.Methods: Tic suppression was studied in 22 adult subjects with Tourette syndrome by using functional magnetic resonance imaging. Images acquired during periods of voluntary tic suppression were compared with images acquired when subjects allowed the spontaneous expression of their ties. The magnitudes of signal change in the images were then correlated with measures of the severity of tic symptoms.Conclusions: Significant changes in signal intensity were seen in the basal ganglia and thalamus and in anatomically connected cortical regions believed to subserve attention-demanding tasks. The magnitudes of regional signal change in the basal ganglia and thalamus correlated inversely with the severity of tic symptoms. These findings suggest that the pathogenesis of ties involves an impaired modulation of neuronal activity in subcortical neural circuits.