The Impact of Sleep Quality on Cognitive Functioning in Parkinson's Disease
The Impact of Sleep Quality on Cognitive Functioning in Parkinson's Disease
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DOI：
10.1017/s1355617711001482
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发表时间：
2012-01-01
影响因子：
2.6
通讯作者：
Cronin-Golomb, Alice
中科院分区：
文献类型：
--
作者：
Stavitsky, Karina;Neargarder, Sandy;Cronin-Golomb, Alice
对于健康个体和失眠症患者来说，睡眠质量不佳与认知测试（尤其是执行功能）的表现下降有关。睡眠障碍和认知缺陷在帕金森病（PD）中都很普遍。超过75%的患者存在睡眠问题，其中睡眠碎片和睡眠效率下降是最常见的睡眠投诉，但其与认知的关系尚不清楚。我们研究了PD患者睡眠质量和认知之间的关系。在35个非痴呆的个人与PD和18个正常对照成年人（NC），睡眠进行了测量，使用24小时腕动记录7天。测试的认知领域包括注意力和执行功能、记忆和心理功能。在这两组中，睡眠不好与注意力/执行功能测试中的表现较差有关，但与记忆力或精神功能无关。在PD组中，注意力/执行功能是由睡眠效率预测的，而记忆和精神功能不是由睡眠质量预测的。运动症状严重程度预测精神和记忆功能。这项研究首次证明PD患者的睡眠质量与认知显著相关，并且它对注意力和执行功能的影响不同，从而进一步加深了我们对睡眠与认知之间联系的理解。(JINS，2012，18，108-117）
In healthy individuals and those with insomnia, poor sleep quality is associated with decrements in performance on tests of cognition, especially executive function. Sleep disturbances and cognitive deficits are both prevalent in Parkinson's disease (PD). Sleep problems occur in over 75% of patients, with sleep fragmentation and decreased sleep efficiency being the most common sleep complaints, but their relation to cognition is unknown. We examined the association between sleep quality and cognition in PD. In 35 non-demented individuals with PD and 18 normal control adults (NC), sleep was measured using 24-hr wrist actigraphy over 7 days. Cognitive domains tested included attention and executive function, memory and psychomotor function. In both groups, poor sleep was associated with worse performance on tests of attention/executive function but not memory or psychomotor function. In the PD group, attention/executive function was predicted by sleep efficiency, whereas memory and psychomotor function were not predicted by sleep quality. Psychomotor and memory function were predicted by motor symptom severity. This study is the first to demonstrate that sleep quality in PD is significantly correlated with cognition and that it differentially impacts attention and executive function, thereby furthering our understanding of the link between sleep and cognition. (JINS, 2012, 18, 108-117)