Stem Cell Extracellular Vesicles in Skin Repair
Stem Cell Extracellular Vesicles in Skin Repair
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DOI：
10.3390/bioengineering6010004
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发表时间：
2018-12-30
影响因子：
4.6
通讯作者：
Gomes, Dawidson Assis
中科院分区：
文献类型：
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作者：
Ferreira, Andrea da Fonseca;Gomes, Dawidson Assis
干细胞细胞外囊泡（EVs）因其具有良好的治疗潜力而受到广泛的研究。来自不同类型干细胞的ev可以改善血管化，并有助于治疗癌症和神经退行性疾病。皮肤是一个复杂的器官，容易受到各种类型的伤害。旨在用干细胞ev恢复上皮组织完整性的策略已经显示出有希望的结果。不同群体的干细胞EVs能够控制炎症，加速皮肤细胞迁移和增殖，控制伤口疤痕，促进血管生成，甚至改善皮肤衰老的迹象。然而，大规模生产这种用于人类治疗的干细胞ev仍然是一个挑战。本文综述了最近的研究，探讨了干细胞ev在皮肤伤口愈合和皮肤年轻化中的潜力，以及它们在治疗中应用的挑战。
Stem cell extracellular vesicles (EVs) have been widely studied because of their excellent therapeutic potential. EVs from different types of stem cell can improve vascularization as well as aid in the treatment of cancer and neurodegenerative diseases. The skin is a complex organ that is susceptible to various types of injury. Strategies designed to restore epithelial tissues' integrity with stem cell EVs have shown promising results. Different populations of stem cell EVs are able to control inflammation, accelerate skin cell migration and proliferation, control wound scarring, improve angiogenesis, and even ameliorate signs of skin aging. However, large-scale production of such stem cell EVs for human therapy is still a challenge. This review focuses on recent studies that explore the potential of stem cell EVs in skin wound healing and skin rejuvenation, as well as challenges of their use in therapy.