EXPRESSION OF CELLULAR ONCOGENES IN HUMAN MALIGNANCIES
EXPRESSION OF CELLULAR ONCOGENES IN HUMAN MALIGNANCIES
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DOI：
10.1126/science.6538699
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
CLINE, MJ
中科院分区：
文献类型：
--
作者：
SLAMON, DJ;DEKERNION, JB;CLINE, MJ
细胞癌基因在某些体外模型系统中参与了恶性转化的诱导，并可能与某些脊椎动物体内的恶性肿瘤有关。本文描述了一项研究，15个细胞癌基因的表达在新鲜的人肿瘤54例，代表20种不同的肿瘤类型。一个以上的细胞癌基因是转录活性在所有的肿瘤检查。在14例患者中，可以研究来自同一器官的正常和恶性组织。在这些患者中的许多人中，某些癌基因的转录活性在恶性组织中比正常组织更大。Cellularfes（猫肉瘤）癌基因，以前不知道在哺乳动物组织中转录，被发现在肺和造血系统恶性肿瘤中活跃。
Cellular oncogenes have been implicated in the induction of malignant transformation in some model systems in vitro and may be related to malignancies in vivo in some vertebrate species. This article describes a study of the expression of 15 cellular oncogenes in fresh human tumors from 54 patients, representing 20 different tumor types. More than one cellular oncogene was transcriptionally active in all of the tumors examined. In 14 patients it was possible to study normal and malignant tissue from the same organ. In many of these patients, the transcriptional activity of certain oncogenes was greater in the malignant than the normal tissue. The cellularfes(feline sarcoma) oncogene, not previously known to be transcribed in mammalian tissue, was found to be active in lung and hematopoietic malignancies.