Multifaceted Function of Myosin-18, an Unconventional Class of the Myosin Superfamily.
Multifaceted Function of Myosin-18, an Unconventional Class of the Myosin Superfamily.
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肌球蛋白 18（肌球蛋白超家族的非常规类别）的多方面功能。
DOI：
10.3389/fcell.2021.632445
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发表时间：
2021
影响因子：
5.5
通讯作者：
Jiu Y
中科院分区：
文献类型：
--
作者：
Ouyang Z;Zhao S;Yao S;Wang J;Cui Y;Wei K;Jiu Y
肌球蛋白是一个多样的马达蛋白超家族，负责真核细胞中基于肌动蛋白的运动性和收缩性。肌球蛋白 - 18家族，包括肌球蛋白 - 18A和肌球蛋白 - 18B，属于一类非传统的肌球蛋白，它们缺乏ATP酶马达活性，近年来才刚刚开始对其在脊椎动物发育和疾病中的功能及分子机制展开研究。肌球蛋白 - 18A在哺乳动物细胞中普遍表达，而肌球蛋白 - 18B则在横纹肌中高度富集。肌球蛋白 - 18家族对于细胞运动、肌节形成和机械感受至关重要，主要通过与其他细胞骨架蛋白和细胞结构相互作用来实现。肌球蛋白 - 18A参与多种细胞内运输过程，如高尔基体运输，并且在粘着斑、应力纤维和片状伪足形成中发挥多种作用。另一方面，肌球蛋白 - 18B参与肌动球蛋白排列和肌节组装，因此与细胞迁移和肌肉收缩相关。Myo18a或Myo18b的突变会导致小鼠心脏发育缺陷，这凸显了它们在肌肉发育和心脏疾病中的关键作用。在这篇综述中，我们回顾了肌球蛋白 - 18的发现历程，总结了对肌球蛋白 - 18A和肌球蛋白 - 18B分子功能不断发展的认识，重点阐述了它们在细胞运动和收缩中既各自独立又紧密相关的功能。此外，我们讨论了与肌球蛋白 - 18密切相关的疾病，特别是心血管缺陷和癌症，同时强调了关于肌球蛋白 - 18尚未解决的问题以及未来潜在的研究方向。
Myosin is a diverse superfamily of motor proteins responsible for actin-based motility and contractility in eukaryotic cells. Myosin-18 family, including myosin-18A and myosin-18B, belongs to an unconventional class of myosin, which lacks ATPase motor activity, and the investigations on their functions and molecular mechanisms in vertebrate development and diseases have just been initiated in recent years. Myosin-18A is ubiquitously expressed in mammalian cells, whereas myosin-18B shows strong enrichment in striated muscles. Myosin-18 family is important for cell motility, sarcomere formation, and mechanosensing, mostly by interacting with other cytoskeletal proteins and cellular apparatus. Myosin-18A participates in several intracellular transport processes, such as Golgi trafficking, and has multiple roles in focal adhesions, stress fibers, and lamellipodia formation. Myosin-18B, on the other hand, participates in actomyosin alignment and sarcomere assembly, thus relating to cell migration and muscle contractility. Mutations of either Myo18a or Myo18b cause cardiac developmental defects in mouse, emphasizing their crucial role in muscle development and cardiac diseases. In this review, we revisit the discovery history of myosin-18s and summarize the evolving understanding of the molecular functions of myosin-18A and myosin-18B, with an emphasis on their separate yet closely related functions in cell motility and contraction. Moreover, we discuss the diseases tightly associated with myosin-18s, especially cardiovascular defects and cancer, as well as highlight the unanswered questions and potential future research perspectives on myosin-18s.
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DOI：
10.1016/j.cub.2015.02.012
发表时间：
2015-03-30
期刊：
Current biology : CB
影响因子：
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作者：
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DOI：
10.1074/jbc.m111.218669
发表时间：
2011-06-17
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Guzik-Lendrum S;Nagy A;Takagi Y;Houdusse A;Sellers JR
通讯作者：
Sellers JR
影响因子：
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