Effects of Oxidative Stress on Airway Epithelium Permeability in Asthma and Potential Implications for Patients with Comorbid Obesity.
Effects of Oxidative Stress on Airway Epithelium Permeability in Asthma and Potential Implications for Patients with Comorbid Obesity.
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DOI：
10.2147/jaa.s402340
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发表时间：
2023
影响因子：
3.2
通讯作者：
中科院分区：
文献类型：
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作者：
美国有2000万成年人和420万儿童患有哮喘，这是一种因各种因素（包括过敏原、污染物和非过敏性触发因素）而导致炎症和气道阻塞的疾病。肥胖是美国另一种高度流行的疾病，是哮喘的主要危险因素，也是全身氧化应激的重要原因。患有哮喘和共病肥胖的人容易发展为严重的哮喘，目前的治疗方法无法充分控制。需要更多的研究来了解当患者患有共病肥胖时，哮喘病理生物学是如何受到影响的。由于气道上皮细胞直接与外界环境相互作用，并与免疫系统密切相互作用，因此了解哮喘和肥胖并存患者的气道上皮细胞与瘦型哮喘患者相比如何改变对于开发更有效的治疗方法至关重要。在这篇综述中，我们讨论了氧化应激如何在两种慢性炎症性疾病，肥胖和哮喘中发挥作用，并提出了这些条件如何可能损害气道上皮的机制。
20 million adults and 4.2 million children in the United States have asthma, a disease resulting in inflammation and airway obstruction in response to various factors, including allergens and pollutants and nonallergic triggers. Obesity, another highly prevalent disease in the US, is a major risk factor for asthma and a significant cause of oxidative stress throughout the body. People with asthma and comorbid obesity are susceptible to developing severe asthma that cannot be sufficiently controlled with current treatments. More research is needed to understand how asthma pathobiology is affected when the patient has comorbid obesity. Because the airway epithelium directly interacts with the outside environment and interacts closely with the immune system, understanding how the airway epithelium of patients with asthma and comorbid obesity is altered compared to that of lean asthma patients will be crucial for developing more effective treatments. In this review, we discuss how oxidative stress plays a role in two chronic inflammatory diseases, obesity and asthma, and propose a mechanism for how these conditions may compromise the airway epithelium.