THE ANTIOXIDANT ACTION OF N-ACETYLCYSTEINE - ITS REACTION WITH HYDROGEN-PEROXIDE, HYDROXYL RADICAL, SUPEROXIDE, AND HYPOCHLOROUS ACID
THE ANTIOXIDANT ACTION OF N-ACETYLCYSTEINE - ITS REACTION WITH HYDROGEN-PEROXIDE, HYDROXYL RADICAL, SUPEROXIDE, AND HYPOCHLOROUS ACID
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DOI：
10.1016/0891-5849(89)90066-x
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发表时间：
1989-01-01
影响因子：
7.4
通讯作者：
BUTLER, J
中科院分区：
文献类型：
--
作者：
ARUOMA, OI;HALLIWELL, B;BUTLER, J
N - 乙酰半胱氨酸在体内和体外已被广泛用作抗氧化剂。因此，人们对其与四种氧化剂的反应进行了研究。N - 乙酰半胱氨酸是次氯酸（H - OCl）的一种强力清除剂；低浓度时就能保护α1 - 抗蛋白酶免受次氯酸的灭活作用。通过脉冲辐解测定，N - 乙酰半胱氨酸与羟基自由基的反应速率常数为1.36×10¹⁰ M⁻¹ s⁻¹。它与过氧化氢的反应也很缓慢，但在我们的检测方法限度内，未检测到N - 乙酰半胱氨酸与超氧阴离子（O₂⁻）发生反应。
N-acetylcysteine has been widely used as an antioxidant in vivo and in vitro. Its reaction with four oxidant species has therefore been examined. N-acetylcysteine is a powerful scavenger of hypochlorous acid (H-OCl); low concentrations are able to protect .alpha.1-antiproteinase against inactivation by HOCl. N-acetylcysteine also reacts with hydroxyl radical with a rate constant of 1.36 .times. 1010 M-1 s-1, as determined by pulse radiolysis. It also reacts slowly with H2O2, but no reaction of N-acetylcysteine with superoxide (O2-) could be detected within the limits of our assay procedures.