The right combination - treatment outcomes among HIV-positive patients initiating first-line fixed-dose antiretroviral therapy in a public sector HIV clinic in Johannesburg, South Africa
The right combination - treatment outcomes among HIV-positive patients initiating first-line fixed-dose antiretroviral therapy in a public sector HIV clinic in Johannesburg, South Africa
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DOI：
10.2147/clep.s145983
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发表时间：
2018-01-01
影响因子：
3.9
通讯作者：
Fox, Matthew P.
中科院分区：
文献类型：
--
作者：
Hirasen, Kamban;Evans, Denise;Fox, Matthew P.
背景：长期坚持抗逆转录病毒治疗（ART）对于实现最佳的HIV治疗结果至关重要。2013年4月在南非推出的固定剂量复方（FDC）单药方案简化了药物服用。我们评估了FDC启动的患者的治疗结果相比，一个类似的多丸ART方案在Johannesburg，SouthAfrica.Methods：我们进行了一项回顾性队列研究的ART初治的HIV阳性非妊娠成人（>= 18岁）无结核病谁启动了一线ART替诺福韦和恩曲他滨或拉米夫定与依法韦仑在Themba Lethu诊所在南非约翰内斯堡。我们比较了开始接受多药丸ART方案（3-5药丸/天; 2011年9月1日至2012年8月31日）的患者与开始接受FDC ART方案（1药丸/天; 2013年9月1日至2014年8月31日）的患者。治疗结果包括脱落（失访和死亡率的组合），错过的医疗访问，和病毒学抑制（病毒载量
Background: Long-term antiretroviral therapy (ART) adherence is critical for achieving optimal HIV treatment outcomes. Fixed-dose combination (FDC) single-pill regimens, introduced in South Africa in April 2013, has simplified pill taking. We evaluated treatment outcomes among patients initiated on a FDC compared to a similar multi-pill ART regimen in Johannesburg, South Africa.Methods: We conducted a retrospective cohort study of ART-naive HIV-positive non-pregnant adult (>= 18 years) patients without tuberculosis who initiated first-line ART on tenofovir and emtricitabine or lamivudine with efavirenz at Themba Lethu Clinic in Johannesburg, South Africa. We compared those initiated on a multi-pill ART regimen (3-5 pills/day; September 1, 2011-August 31, 2012) to those initiated on a FDC ART regimen (one pill/day; September 1, 2013-August 31, 2014). Treatment outcomes included attrition (combination of lost to follow-up and mortality), missed medical visits, and virologic suppression (viral load