Does time interval between surgery and intraperitoneal chemotherapy administration in advanced ovarian cancer carry a prognostic impact? An NRG Oncology/Gynecologic Oncology Group study ancillary study.
Does time interval between surgery and intraperitoneal chemotherapy administration in advanced ovarian cancer carry a prognostic impact? An NRG Oncology/Gynecologic Oncology Group study ancillary study.
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DOI：
10.1016/j.ygyno.2016.10.003
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发表时间：
2016-12
影响因子：
4.7
通讯作者：
Copeland LJ
中科院分区：
文献类型：
--
作者：
Garcia-Soto AE;Java JJ;Nieves Neira W;Pearson JM;Cohn DE;Lele SB;Tewari KS;Walker JL;Alvarez Secord A;Armstrong DK;Copeland LJ
使用来自合作组临床试验的辅助数据，确定从手术到腹腔内（IP）化疗（TSIC）开始的时间与III期上皮性卵巢癌（EOC）患者生存率的关系。对420例根据GOG-0114接受IP化疗的III期EOC患者和172例接受IP化疗的III期EOC患者的数据进行了审查。采用考克斯比例风险模型评估独立预后因素，并估计其对PFS和OS的协变量调整效应。中位TSIC为62.5天（四分位数间距28-83）。GOG-0114组患者的中位TSIC长于GOG-172组患者（83天vs 26天，p <0.001）。TSIC与PFS显著相关（P = 0.049）：TSIC（天数）每增加10%，进展风险降低3%。在该模型中，TSIC与OS无显著相关性。在线性回归模型中，大体残留病变与较短的TSIC显著相关（R2 - 0.141，95% CI-0.217，-0.064，p < 0.001）。当仅考虑GOG-172的数据时，未发现TSIC与PFS或OS之间存在统计学显著相关性。在这项辅助数据研究中，TSIC与III期上皮性卵巢癌患者的OS改善无关。在整个队列中，TSIC与PFS显著相关，表明PFS随TSIC延长而增加。然而，当仅对GOG 172或GOG 114的数据进行单独分析时，未发现这一点。因此，IP化疗开始和手术时间之间的关系需要进一步研究。
To determine the relationship of the time from surgery to intraperitoneal (IP) chemotherapy (TSIC) initiation with survival of patients with stage III epithelial ovarian cancer (EOC) patients using ancillary data from cooperative group clinical trials. Data from 420 patients with stage III EOC treated with IP chemotherapy under GOG-0114 and 172 were reviewed. The Cox proportional hazards model was used to evaluate independent prognostic factors and estimate their covariate-adjusted effects on PFS and OS. The median TSIC was 62.5 days (interquartile range 28-83). The median TSIC was longer for patients in GOG-0114 vs those in GOG-172 (83 vs 26 days, p <0.001). TSIC was significantly associated (P = 0.049) with PFS: each 10% increase in TSIC (days) decreases the risk of progression by 3%. TSIC was not significantly associated with OS in this model. In a linear regression model, gross residual disease was significantly associated with shorter TSIC (R2 -0.141, 95%CI -0.217, -0.064, p < 0.001). When only data from GOG-172 were considered, no statistical significant association was found between TSIC and PFS or OS. In this ancillary data study, TSIC was not associated with improved OS in patients with stage III epithelial ovarian cancer. TSIC was significantly associated with PFS for the entire cohort, suggesting increase in PFS with longer TSIC. However, this was not found when only data from GOG 172 or GOG 114 were analyzed separately. Hence, the relationship between IP chemotherapy initiation and time from surgery needs to be studied further.
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影响因子：
45.3
作者：
Tewari, Devansu;Java, James J.;Chan, John K.
通讯作者：
Chan, John K.
影响因子：
45.3
作者：
Markman, M;Bundy, BN;Sickel, J
通讯作者：
Sickel, J
影响因子：
2.5
作者：
MARQUARDT, DW
通讯作者：
MARQUARDT, DW
影响因子：
1.6
作者：
Pearson, Karl
通讯作者：
Pearson, Karl
影响因子：
45.3
作者：
Markman, M;Markman, J;Belinson, J
通讯作者：
Belinson, J