Post-recovery COVID-19 and incident heart failure in the National COVID Cohort Collaborative (N3C) study.
Post-recovery COVID-19 and incident heart failure in the National COVID Cohort Collaborative (N3C) study.
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恢复后COVID-19和国家共同队列合作（N3C）研究中的事件心力衰竭。
DOI：
10.1038/s41467-022-31834-y
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发表时间：
2022-07-15
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
在COVID-19感染中注意到心脏受累。然而，尚未在全国代表性的大型人群中研究恢复后COVID-19与新发心力衰竭之间的关系。我们使用国家COVID队列协作研究的数据，检查了在美国住院的587，330名患者（257，075名患有COVID-19，330，255名没有）的康复后结局。因COVID-19住院的患者年龄较大（51岁对46岁），男性更常见（49%对42%），白色较少（61%对69%）。在平均367天的随访中，发生了10，979起心力衰竭事件。调整后，COVID-19住院与心力衰竭事件风险增加45%相关（风险比= 1.45; 95%置信区间：1.39-1.51），在年龄较小的患者中相关性更明显（P-相互作用= 0.003）、白色（P-相互作用= 0.005）或已确诊心血管疾病（P-相互作用= 0.005）。总之，COVID-19住院与心力衰竭事件风险增加相关。康复后COVID-19与心力衰竭事件之间的关系尚未进行大规模研究。在本文中，作者使用了美国约60万名患者的电子健康记录，发现患有COVID-19的住院患者的出院后心力衰竭发生率高于未患COVID-19的患者。
Cardiac involvement has been noted in COVID-19 infection. However, the relationship between post-recovery COVID-19 and development of de novo heart failure has not been investigated in a large, nationally representative population. We examined post-recovery outcomes of 587,330 patients hospitalized in the United States (257,075 with COVID-19 and 330,255 without), using data from the National COVID Cohort Collaborative study. Patients hospitalized with COVID-19 were older (51 vs. 46 years), more often male (49% vs. 42%), and less often White (61% vs. 69%). Over a median follow up of 367 days, 10,979 incident heart failure events occurred. After adjustments, COVID-19 hospitalization was associated with a 45% higher hazard of incident heart failure (hazard ratio = 1.45; 95% confidence interval: 1.39–1.51), with more pronounced associations among patients who were younger (P-interaction = 0.003), White (P-interaction = 0.005), or who had established cardiovascular disease (P-interaction = 0.005). In conclusion, COVID-19 hospitalization is associated with increased risk of incident heart failure. The relationship between post-recovery COVID-19 and incident heart failure has not been investigated at scale. Here, the authors use electronic health records for ~600,000 patients in the US and find a higher rate of post-discharge incident heart failure in those hospitalised with COVID-19 than without.
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影响因子：
24
作者：
Puntmann, Valentina O.;Carerj, M. Ludovica;Nagel, Eike
通讯作者：
Nagel, Eike
DOI：
10.1001/jama.2020.19759
发表时间：
2020-10-20
期刊：
JAMA
影响因子：
--
作者：
Cutler DM;Summers LH
通讯作者：
Summers LH
DOI：
10.1093/jamia/ocaa196
发表时间：
2021-03-01
影响因子：
6.4
作者：
Haendel, Melissa A.;Chute, Christopher G.;Gersing, Ken R.
通讯作者：
Gersing, Ken R.
影响因子：
18.2
作者：
Rey, Juan R.;Caro-Codon, Juan;Merino, Jose L.
通讯作者：
Merino, Jose L.
影响因子：
39.3
作者：
Jin Y;Ji W;Yang H;Chen S;Zhang W;Duan G
通讯作者：
Duan G