Registration of in vivo prostate MRI and pseudo-whole mount histology using Local Affine Transformations guided by Internal Structures (LATIS).
Registration of in vivo prostate MRI and pseudo-whole mount histology using Local Affine Transformations guided by Internal Structures (LATIS).
复制标题
DOI：
10.1002/jmri.24629
复制
发表时间：
2015-04
影响因子：
4.4
通讯作者：
Metzger, Gregory J.
中科院分区：
文献类型：
--
作者：
Kalavagunta, Chaitanya;Zhou, Xiangmin;Schmechel, Stephen C.;Metzger, Gregory J.
关键词：
To present a novel registration approach called LATIS (Local Affine Transformation assisted by Internal Structures) for co-registering post prostatectomy pseudo-whole mount (PWM) pathological sections with in vivo MRI (Magnetic Resonance Imaging) images. Thirty-five patients with biopsy-proven prostate cancer were imaged at 3T with an endorectal coil. Excised prostate specimens underwent quarter mount step-section pathologic processing, digitization, annotation and assembly into a PWM. Manually annotated macro-structures on both pathology and MRI were used to assist registration using a relaxed local affine transformation approximation. Registration accuracy was assessed by calculation of the dice similarity coefficient (DSC) between transformed and target capsule masks and least square distance between transformed and target landmark positions. LATIS registration resulted in a DSC value of 0.991±0.004 and registration accuracy of 1.54±0.64 mm based on identified landmarks common to both datasets. Image registration performed without the use of internal structures led to an 87% increase in landmark based registration error. Derived transformation matrices were used to map regions of pathologically defined disease to MRI. LATIS was used to successfully co-register digital pathology with in vivo MRI to facilitate improved correlative studies between pathologically identified features of prostate cancer and multi-parametric MRI.
登录
查看更多内容
影响因子：
4.4
作者：
Langer, Deanna L.;van der Kwast, Theodorus H.;Haider, Masoom A.
通讯作者：
Haider, Masoom A.
影响因子：
4.8
作者：
DICE, LR
通讯作者：
DICE, LR
影响因子：
1.9
作者：
McLaughlin, Patrick W;Narayana, Vrinda;Roberson, Peter L
通讯作者：
Roberson, Peter L
DOI：
10.1016/0022-247x(74)90025-0
发表时间：
1974-01-01
影响因子：
1.3
作者：
EKELAND, I
通讯作者：
EKELAND, I
影响因子：
3.8
作者：
Boldea, Vlad;Sharp, Gregory C.;Sarrut, David
通讯作者：
Sarrut, David