A mosquito sperm's journey from male ejaculate to egg: Mechanisms, molecules, and methods for exploration.
A mosquito sperm's journey from male ejaculate to egg: Mechanisms, molecules, and methods for exploration.
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DOI：
10.1002/mrd.22653
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发表时间：
2016-10
影响因子：
2.5
通讯作者：
Harrington, Laura C.
中科院分区：
文献类型：
--
作者：
Degner, Ethan C.;Harrington, Laura C.
蚊子精子在雌性生殖道中的命运已经被零星和不完全地解决，导致我们对最终导致受精的精子-雌性相互作用的理解存在重大差距。与其他双翅目昆虫一样，蚊子的精子有一个复杂的旅程，到达它们的最终目的地--卵子。交配后，精子在授精部位停留很短的时间，在那里它们被过度激活，并迅速聚集在受精子管的入口附近。几分钟之内，它们沿着狭窄的管道到达受精囊，可能是通过雌性运输和精子运动的共同努力。雌性将精子储存起来，并将它们终生保存在这些永久性的储存器官中。当她准备好了，女性协调释放精子与排卵，并下降卵子受精。虽然这一过程已经通过显微镜进行了很好的研究，但关于协调精子运动、通过生殖道运动、维持和使用的分子过程仍然存在许多问题。在这篇综述中，我们描述了目前对蚊子精子到卵子的旅程的理解，突出了我们对蚊子生殖生物学知识的差距。当蚊子中的信息不足时，我们描述了其他生物（例如黑腹果蝇）中的类似过程，作为比较的基础，并且我们建议未来的研究领域，以阐明精子如何成功穿过雌性生殖道。这些研究可能产生分子靶点，可用于控制病媒物种的种群。摩尔Reprod. Dev. 83：897-911，2016.© 2016作者。《分子生殖与发育》（Molecular Reproduction and Development），Wiley Periodicals，Inc.
The fate of mosquito sperm in the female reproductive tract has been addressed sporadically and incompletely, resulting in significant gaps in our understanding of sperm‐female interactions that ultimately lead to fertilization. As with other Diptera, mosquito sperm have a complex journey to their ultimate destination, the egg. After copulation, sperm spend a short time at the site of insemination where they are hyperactivated and quickly congregate near the entrance of the spermathecal ducts. Within minutes, they travel up the narrow ducts to the spermathecae, likely through the combined efforts of female transport and sperm locomotion. The female nourishes sperm and maintains them in these permanent storage organs for her entire life. When she is ready, the female coordinates the release of sperm with ovulation, and the descending egg is fertilized. Although this process has been well studied via microscopy, many questions remain regarding the molecular processes that coordinate sperm motility, movement through the reproductive tract, maintenance, and usage. In this review, we describe the current understanding of a mosquito sperm's journey to the egg, highlighting gaps in our knowledge of mosquito reproductive biology. Where insufficient information is available in mosquitoes, we describe analogous processes in other organisms, such as Drosophila melanogaster, as a basis for comparison, and we suggest future areas of research that will illuminate how sperm successfully traverse the female reproductive tract. Such studies may yield molecular targets that could be manipulated to control populations of vector species. Mol. Reprod. Dev. 83: 897–911, 2016. © 2016 The Authors. Molecular Reproduction and Development Published by Wiley Periodicals, Inc.
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影响因子：
3.3
作者：
Avila, Frank W.;Cohen, Allie B.;Wolfner, Mariana F.
通讯作者：
Wolfner, Mariana F.
影响因子：
3.7
作者：
Boyer S;Toty C;Jacquet M;Lempérière G;Fontenille D
通讯作者：
Fontenille D
影响因子：
2.2
作者：
ADLAKHA, V;PILLAI, MKK
通讯作者：
PILLAI, MKK
影响因子：
2.2
作者：
CLEMENTS, AN;POTTER, SA
通讯作者：
POTTER, SA
DOI：
10.1016/0020-1790(87)90075-8
发表时间：
1987-01-01
期刊：
INSECT BIOCHEMISTRY
影响因子：
--
作者：
AIGAKI, T;KASUGA, H;OSANAI, M
通讯作者：
OSANAI, M