Psychological side-effects of clomiphene citrate and human menopausal gonadotrophin
Psychological side-effects of clomiphene citrate and human menopausal gonadotrophin
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DOI：
10.1080/01443610400022983
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发表时间：
2005-06-01
影响因子：
3.1
通讯作者：
Stewart, D
中科院分区：
文献类型：
--
作者：
Choi, SH;Shapiro, H;Stewart, D
Objective.本研究评估了克罗米芬（CC）和hMG在接受生育治疗的妇女中的心理副作用。这项研究是一项横断面的自我报告调查，454名妇女在不同阶段的治疗不孕症。在研究时，139名妇女没有服用生育药物，315名妇女服用了一个或多个周期的CC或hMG。所有受试者被要求完成状态-特质焦虑量表（STAI）。服用CC或hMG的女性还被要求完成一份关于药物副作用的自我管理问卷。结果。在CC组（n = 162）和hMG组（n = 153）中，分别有77.8%（126/162）和94.8%（145/153）报告了至少一种副作用。在CC组和hMG组中，易怒、情绪波动、情绪低落和腹胀的发生率都很高，hMG组报告的平均副作用数量更高（CC组为4.4 +/- 3.7，hMG组为6.8 +/- 3.7，p < 0.001）。CC组、hMG组和未用药组的平均状态焦虑和特质焦虑评分无显著差异。然而，三个副作用组（报告I至4，5至7和超过7个副作用的组）的状态（df = 2，F = 8.7，p < 0.001）和特质（df = 2，F = 11）的平均得分存在显著差异。9，p < 0.001）服用生育药物妇女的焦虑。服用CC或hMG的女性报告了高频率的心理副作用，并应在治疗前告知这些副作用。
Objective. This study evaluated the psychological side-effects of clomiphene citrate (CC) and hMG in women undergoing fertility treatment.Method. This study was a cross-sectional, self-report survey of 454 women at various stages of treatment for infertility. At the time of study, 139 women had not taken fertility drugs and 315 women had taken one or more cycles of CC or hMG. All subjects were asked to complete the State-Trait Anxiety Inventory (STAI). Women taking CC or hMG were also asked to complete a self-administered questionnaire on the side-effects of their medications.Result(s). In the CC group (n = 162) and hMG group (n = 153), 77.8% (126 of 162) and 94.8% (145 of 153) reported at least one side-effect, respectively. Irritability, mood swings, feeling down, and bloating had high frequencies in both CC and hMG groups, with a higher mean number of side effects reported in the hMG group (4.4 +/- 3.7 for the CC group and 6.8 +/- 3.7 for the hMG group, p < 0.001). There was no significant difference among the CC, hMG and no medication groups for mean state and trait anxiety scores. However, there were significant differences among the three side-effect groups (those who reported I to 4, 5 to 7, and more than 7 side-effects) for the mean scores of state (df = 2, F = 8.7, p < 0.001) and trait (df = 2, F = 11. 9, p < 0.001) anxiety in women taking fertility drugs.Conclusion(s). Women taking CC or hMG reported high frequencies of psychological side-effects, and should be advised of these before treatment.