Neural crest cell migration in the developing embryo
Neural crest cell migration in the developing embryo
复制标题
DOI：
10.1016/0962-8924(93)90089-j
复制
发表时间：
1993-01-01
影响因子：
19
通讯作者：
Bronner-Fraser, Marianne
中科院分区：
文献类型：
--
作者：
Bronner-Fraser, Marianne
神经嵴是脊椎动物特有的胚胎细胞群，在神经胚形成后，随着神经板折叠形成神经管而出现。神经嵴细胞迁移的起始在管闭合后不久以头-尾（吻尾）波进行。迁移后，这些细胞以高度模式化的方式穿过邻近组织。它们定位于胚胎内不同但具有特征性的部位，随后分化成广泛的衍生物，包括大部分外周神经系统、色素细胞、肾上腺髓质和面部骨骼。神经嵴细胞沿着胚胎轴有不同的亚群，来自不同轴水平的细胞遵循不同的迁移途径，并经常形成不同的衍生物。
The neural crest, an embryonic cell population unique to vertebrates, emerges after neurulation as the neural plate folds to form the neural tube. Initiation of neural crest cell migration proceeds in a head-to-tailward (rostrocaudal) wave, shortly following tube closure. After emigration, these cells move in a highly patterned fashion through neighbouring tissues. They localize in diverse but characteristic sites within the embryo and subsequently differentiate into a wide array of derivatives, including most of the peripheral nervous system, pigment cells, the adrenal medulla and the facial skeleton. There are distinct subpopulations of neural crest cells along the embryonic axis, with cells that arise from different axial levels following distinct migratory pathways and often forming divergent derivatives.