Mechanical properties and reliability of glass-ceramic foam scaffolds for bone repair
Mechanical properties and reliability of glass-ceramic foam scaffolds for bone repair
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DOI：
10.1016/j.matlet.2013.12.037
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发表时间：
2014-03-01
影响因子：
3
通讯作者：
Vitale-Brovarone, Chiara
中科院分区：
文献类型：
--
作者：
Baino, Francesco;Vitale-Brovarone, Chiara
发展可靠的合成支架来修复承重骨的巨大缺陷是硬组织再生医学的关键挑战之一。本研究通过微计算机断层扫描研究，研究了海绵复制制备的具有骨样三维骨小梁结构的实验微晶玻璃支架的力学性能。该支架的抗压强度为18 Mpa，弹性模数约为380 Mpa，威布尔模数为4，断裂能为544 kJ m(-3)。将这些结果与生物陶瓷支架和人类松质骨的文献报道进行比较，发现它们相似甚至更好。这些关键的力学数据，再加上独特的泡沫状多孔结构，表明这种类型的支架在承重骨组织工程应用中具有巨大的潜力。(C)2013爱思唯尔B.V.保留所有权利。
The development of reliable, synthetic scaffolds to repair large defects in load-bearing bones is one of the key challenges of regenerative medicine of hard tissues. This study addresses the mechanical properties of experimental glass-ceramic scaffolds fabricated by sponge replication and exhibiting a bone-like 3-D trabecular architecture, as assessed by micro-computed tomography investigations. The scaffolds have a strength of 18 MPa, an elastic modulus around 380 MPa, a Weibull modulus of 4 and a fracture energy of 544 kJ m(-3) when tested in compression. Such results were compared with and found similar or even superior to those reported in the literature for bioceramic scaffolds and human cancellous bone. These key mechanical data, together with the peculiar foam-like porous architecture, indicate the great potential of this type of scaffolds for use in load-bearing bone tissue engineering applications. (C) 2013 Elsevier B.V. All rights reserved.