Giant cell tumors of the clivus: Case report and literature review.
Giant cell tumors of the clivus: Case report and literature review.
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DOI：
10.4103/2152-7806.170459
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发表时间：
2015
影响因子：
--
通讯作者：
Yoshida K
中科院分区：
文献类型：
--
作者：
Shibao S;Toda M;Yoshida K
斜坡巨细胞瘤（GCT）是非常罕见的，迄今为止只有8例报告，恶性转化是相当罕见的。在此，我们报告一例未受控制的斜坡骨巨细胞瘤，并回顾文献。一名25岁的男子出现复视1个月。计算机断层扫描和磁共振成像显示斜坡肿瘤。采用鼻内镜下经蝶入路（EEA），因大出血行部分切除术。组织学检查显示GCT。放射治疗后，肿瘤复发; EEA和前经岩骨入路分别进行第二次和第三次手术。MIB-1指数从4.2%增加到26.3%。GCT由于其位置、血管分布和恶性转化的可能性而难以治疗。
Clival giant cell tumors (GCTs) are extremely rare with only eight cases reported to date, and malignant transformation is quite rare. Herein, we report a case of an uncontrolled clival GCT, which was transformed malignant, and review the literature. A 25-year-old man experienced double vision for 1 month. Computed tomography and magnetic resonance imaging revealed a clival tumor. The endonasal endoscopic transsphenoidal approach (EEA) was used, and partial resection was performed because of massive bleeding. Histological examination showed a GCT. After radiation therapy, the tumor recurred; the EEA and the anterior transpetrosal approaches were used to perform second and third operations, respectively. The MIB-1 index increased from 4.2% to 26.3%. GCTs are difficult to treat because of their location, vascularity, and the potential for malignant transformation.