An implantable RF solenoid for magnetic resonance microscopy and microspectroscopy.
An implantable RF solenoid for magnetic resonance microscopy and microspectroscopy.
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DOI：
10.1109/tbme.2011.2178239
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发表时间：
2012-08
期刊：
影响因子：
--
通讯作者：
Judy JW
中科院分区：
文献类型：
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作者：
Rivera DS;Cohen MS;Clark WG;Chu AC;Nunnally RL;Smith J;Mills D;Judy JW
微型螺线管通常可以增强小体积核磁共振成像和光谱；然而，目前还没有适用于患者的技术。我们提出了一种可植入的微线圈，可用于不同的临床应用，具有微升线圈体积。该设计松散地基于可植入的深度电极，其中软管作为衬底，在植入过程中将金属针头插入到管中。其目标是为不易被表面线圈访问的结构提供增强的信噪比(SNR)。第一代原型是为植入到2厘米处而设计的，并为显微镜提供了初步的概念验证。随后，我们优化了设计，以最大限度地减少引线电感的影响，从而使植入深度(4厘米)的长度增加一倍。第二代设计在扩展到4厘米时，与原始设计相比，信噪比估计提高了30%以上。阻抗测量表明，该装置在体温盐水中稳定可达24小时。我们评估了该装置在3T时的信噪比和MR相关加热。可植入的微线圈可以区分脂肪峰和水峰，并分辨亚毫米特征。
Miniature solenoids routinely enhance small volume nuclear magnetic resonance imaging and spectroscopy; however, no such techniques exist for patients. We present an implantable microcoil for diverse clinical applications, with a microliter coil volume. The design is loosely based on implantable depth electrodes, in which a flexible tube serves as the substrate, and a metal stylet is inserted into the tube during implantation. The goal is to provide enhanced signal-to-noise ratio (SNR) of structures that are not easily accessed by surface coils. The first-generation prototype was designed for implantation up to 2 cm, and provided initial proof-of-concept for microscopy. Subsequently, we optimized the design to minimize the influence of lead inductances, and to thereby double the length of the implantable depth (4 cm). The second-generation design represents an estimated SNR improvement of over 30% as compared to the original design when extended to 4 cm. Impedance measurements indicate that the device is stable for up to 24 h in body temperature saline. We evaluated the SNR and MR-related heating of the device at 3T. The implantable microcoil can differentiate fat and water peaks, and resolve submillimeter features.