Trends in Bronchopulmonary Dysplasia Among Extremely Preterm Infants in Japan, 2003-2016
Trends in Bronchopulmonary Dysplasia Among Extremely Preterm Infants in Japan, 2003-2016
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DOI：
10.1016/j.jpeds.2020.11.041
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发表时间：
2021-02-22
影响因子：
5.1
通讯作者：
Ohga, Shouichi
中科院分区：
文献类型：
--
作者：
Nakashima, Toshinori;Inoue, Hirosuke;Ohga, Shouichi
目的探讨极早产儿支气管肺发育不良（BPD）的近期趋势及其危险因素。研究设计回顾了2003年至2016年期间在日本新生儿研究网络附属医院登记的19370例妊娠22-27周出生的婴儿的人口统计学和临床数据。结果19370例新生儿中，2244例（11.6%）在月经后36周死亡，其中1144例（11.6%）在月经后36周死亡，2244例（11.6%）在月经后36周死亡。死亡率从2003年的19.0%（99%CI，15.7%-22.8%）降至2016年的8.0%（99%CI，6.2%-10.3%）。在17126名幸存者中，7792名（45.5%）婴儿发生BPD，其比例从2003年的41.4%（99%CI，36.5%-46.4%）显著增加至2016年的52.0%（99%CI，48.2%-55.9%）。对存活者的多变量分析显示，BPD与（3）4周补充供氧或有创通气、出生体重= 4周无创正压通气、绒毛膜炎、
Objective To investigate recent trends in bronchopulmonary dysplasia (BPD) and its risk factors among extremely preterm infants.Study design Demographic and clinical data were reviewed for 19 370 infants born at 22-27 weeks of gestation registered in the affiliated hospitals of the Neonatal Research Network of Japan between 2003 and 2016. We investigated the overall survival and prevalence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age and risk factors for developing BPD among the survivors.Results Among 19 370 infants, 2244 (11.6%) died by 36 weeks' postmenstrual age. The mortality rate decreased from 19.0%(99% CI, 15.7%-22.8%) in 2003 to 8.0%(99% CI, 6.2%-10.3%) in 2016. Among 17 126 survivors, BPD developed in 7792 (45.5%) infants, and its proportion significantly increased from 41.4% (99% CI, 36.5%-46.4%) in 2003 to 52.0% (99% CI, 48.2%-55.9%) in 2016. A multivariable analysis of the survivors showed a positive association of BPD with (3)4 weeks' supplemental oxygen or invasive ventilation, birth weight = 4 weeks' noninvasive positive pressure ventilation, chorioamnionitis,