GOUT AND CORONARY HEART-DISEASE - THE FRAMINGHAM-STUDY
GOUT AND CORONARY HEART-DISEASE - THE FRAMINGHAM-STUDY
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DOI：
10.1016/0895-4356(88)90127-8
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发表时间：
1988-01-01
影响因子：
7.2
通讯作者：
CASTELLI, WP
中科院分区：
文献类型：
--
作者：
ABBOTT, RD;BRAND, FN;CASTELLI, WP
在最初入组Frachial研究的5209例受试者中，检查了与利尿剂使用无关的痛风与冠心病发生之间的关系。基于32年的随访，男性（3.2/1000）的痛风两年发病率是女性（0.5/1000）的6倍。男女痛风发病率与年龄无明显关系。在从未接受过利尿剂治疗的男性中，与未接受过痛风治疗的男性相比，痛风患者的冠心病发病率高出60%（95%置信区间，1.1-2.2），主要归因于心绞痛发病率高出两倍（95%置信区间，1.2-3.1）。虽然痛风通常与其他致动脉粥样硬化的危险因素有关，但控制收缩压、总胆固醇、酒精摄入量、体重指数和糖尿病并不能改变痛风对男性先前冠状动脉事件的影响。对于女性来说，痛风和冠心病之间没有明显的联系。我们的结论是痛风，无关的摄入利尿剂，赋予额外的风险，冠心病的男性，无法解释的临床测量的危险因素。
The relationship between gout, not associated with the use of diuretics, and the development of coronary heart disease was examined in 5209 subjects originally enrolled in the Framingham Study. Based on 32 years of follow-up, the two year incidence of gout was six times greater in men (3.2/1000) as compared to women (0.5/1000). For both sexes, the incidence of gout showed no clear relationship with age. Among men who never received diuretics, those afflicted by gout, as compared to those without gout, experienced a 60% excess of coronary heart disease (95% confidence limits, 1.1-2.2), primarily attributed to a two-fold excess of angina pectoris (95% confidence limits, 1.2-3.1). Although gout was usually associated with other atherogenic risk factors, control of systolic blood pressure, total cholesterol, alcohol intake, body mass index, and diabetes failed to alter the effect of gout on the preceding coronary events in men. For women, there were no significant associations between gout and coronary heart disease. We conclude that gout, unrelated to the intake of diuretics, imparts an additional risk of coronary heart disease in men, unexplained by clinically measured risk factors.