Influence of sigma-1 receptor modulators on ethanol-induced conditioned place preference in the extinction-reinstatement model
Influence of sigma-1 receptor modulators on ethanol-induced conditioned place preference in the extinction-reinstatement model
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DOI：
10.1097/fbp.0b013e32834eafe6
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发表时间：
2012-02-01
影响因子：
1.6
通讯作者：
Umathe, Sudhir N.
中科院分区：
文献类型：
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作者：
Bhutada, Pravinkumar S.;Mundhada, Yogita R.;Umathe, Sudhir N.
据报道，Sigma-1 受体激动剂可以增强滥用药物的奖赏效应，而拮抗剂则可以阻断滥用药物的奖赏效应。然而，它们对恢复乙醇诱导的条件性位置偏好（CPP）的影响尚未被探索。因此，我们研究了 sigma-1 受体激动剂 2-(4-吗啉代)乙基-1-苯基环己烷-1-甲酸 (PRE-084) 和 sigma-1 受体拮抗剂 N-[2-(3,4-二氯苯基)乙基]-N-甲基-2-(二甲氨基)乙胺二氢溴酸盐 (BD-1047) 在获取、表达和恢复方面的能力使用成年雄性瑞士小鼠乙醇诱导的 CPP。 BD-1047（0.1-10μg/小鼠，脑室内）剂量依赖性地阻断乙醇诱导的CPP的发育、表达和恢复，而PRE-084（0.01-10μg/小鼠，脑室内）剂量依赖性地恢复熄灭的反应。 PRE-084和BD-1047单独或与乙醇组合的这些作用不影响运动活动。因此，得出的结论是，sigma-1受体配体可以调节乙醇条件性增强作用的获得、表达和恢复，而其自身没有增强或厌恶影响。这些结果为越来越多的关于乙醇成瘾药物治疗中 sigma-1 受体调节的文献提供了补充。行为药理学 23:25-33 (C) 2012 Wolters Kluwer Health |利平科特·威廉姆斯和威尔金斯。
Sigma-1 receptor agonists are reported to augment and antagonists block the rewarding effects of drugs of abuse. However, their effect on reinstatement of ethanol-induced conditioned place preference (CPP) has not yet been explored. Therefore, we investigated the ability of 2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate (PRE-084), a sigma-1 receptor agonist, and N-[2-(3,4-dichlorophenyl) ethyl]-N-methyl-2-(dimethylamino) ethylamine dihydrobromide (BD-1047), a sigma-1 receptor antagonist, on the acquisition, expression, and reinstatement of ethanol-induced CPP using adult male Swiss mice. BD-1047 (0.1-10 mu g/mouse, intracerebroventricularly) dose-dependently blocked the development, expression, and reinstatement of ethanol-induced CPP, and PRE-084 (0.01-10 mu g/mouse, intracerebroventricularly) dose-dependently reinstated the extinguished response. These effects of PRE-084 and BD-1047 alone or in combination with ethanol did not influence the motor activity. Therefore, it is concluded that sigma-1 receptor ligands can modulate the acquisition, expression, and reinstatement of conditioned reinforcing effects of ethanol with no reinforcing or aversive influence of their own. The results add to the growing literature on sigma-1 receptor modulation in the pharmacotherapy of ethanol addiction. Behavioural Pharmacology 23:25-33 (C) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.