Organization of somatosensory cortex in the laboratory rat (Rattus norvegicus):: Evidence for two lateral areas joined at the representation of the teeth
Organization of somatosensory cortex in the laboratory rat (Rattus norvegicus):: Evidence for two lateral areas joined at the representation of the teeth
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DOI：
10.1002/cne.10909
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发表时间：
2003-12-01
影响因子：
2.5
通讯作者：
Catania, KC
中科院分区：
文献类型：
--
作者：
Remple, MS;Henry, EC;Catania, KC
侧体感觉区尚未在大鼠中进行详细的探索，该区域的组织理论主要基于解剖追踪实验。我们通过微电极记录研究了该区域的地形，这些记录与细胞色素氧化酶（CO）处理的扁平皮质切片有关。确定了两个外侧体感区域，每个区域都包含身体的完整表征。一个更大、更内侧的表征形成了S1沿着头部区域的背尾轴的镜像，与先前确定的次级体感区（S2）相对应。一个更小、更侧向的表征形成了S2沿前肢和后肢区域的背尾轴的镜像，可能与其他哺乳动物中发现的顶叶腹侧区（PV）相对应。我们还研究了牙列的表征，并确定了对牙齿刺激有反应的皮层区域。下切牙位于S1下唇区域的吻侧，上切牙位于S1颊垫区域的外侧。上下门牙位于舌头的两侧。远侧皮质的另一大片区域对两个门牙都有反应。最后，5个co密集模块被一致地识别为吻侧和侧面的S1面部表征，我们称之为OM1， OM2, OM3， FM和HM。这些模块与代表S1的下门牙（OM1）和舌头（OM2）区域的生理识别区域以及代表S2和PV的混合齿（OM3）、前肢（FM1）和后肢（HM）区域紧密对应。(C) 2003 Wiley-Liss, Inc。
Lateral somatosensory areas have not been explored in detail in rats, and theories on the organization of this region are based largely on anatomical tracing experiments. We investigated the topography of this region by using microelectrode recordings, which were related to flattened cortical sections processed for cytochrome oxidase (CO). Two lateral somatosensory areas were identified, each containing a complete representation of the body. A larger, more medial representation formed a mirror image of S1 along the rostrocaudal axis of the head region corresponding to the previously identified secondary somatosensory area (S2). A smaller, more lateral representation formed a mirror image of S2 along the rostrocaudal axis of the forelimb and hindlimb regions and likely corresponds to the parietal ventral area (PV) identified in other mammals. We also investigated the representation of the dentition and identified regions of cortex responsive to tooth stimulation. The lower incisor representation was rostral to the lower lip region of S1, and the upper incisor representation was lateral to the buccal pad region of S1. The upper and lower incisors flanked the tongue representation. An additional large region of far lateral cortex responded to both incisors. Finally, five CO-dense modules were consistently identified rostral and lateral to the S1 face representation, which we refer to as OM1, OM2, OM3, FM, and HM. These modules closely correspond to the physiologically identified areas representing the lower incisor (OM1) and tongue (OM2) regions of S1 and the mixed tooth (OM3), forelimb (FM1), and hindlimb (HM) representations of S2 and PV. (C) 2003 Wiley-Liss, Inc.