Total synthesis of Ciliatamides A-C: stereochemical revision and the natural product-guided synthesis of unnatural analogs.
Total synthesis of Ciliatamides A-C: stereochemical revision and the natural product-guided synthesis of unnatural analogs.
复制标题
纤毛酰胺 A-C 的全合成：立体化学修正和天然产物引导的非天然类似物的合成。
DOI：
10.1021/ol801842v
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发表时间：
2008
期刊：
影响因子：
5.2
通讯作者：
Lindsley,CraigW
中科院分区：
文献类型：
--
作者：
Lewis,JanaA;Daniels,RNathan;Lindsley,CraigW
完成了Ciliatamides A-C的第一个全合成，导致报告的立体化学从（S，S）到（R，R）对映体的修订。由于加速的途径，还制备了超过50种非天然纤毛虫酰胺类似物的文库。
The first total synthesis of Ciliatamides A−C was completed, leading to a revision of the reported stereochemistry from (S,S) to the (R,R) enantiomers. Due to the expedited route, a library of over 50 unnatural ciliatamide analogs was also prepared.