Thyroid Hormone Mediated Modulation of Energy Expenditure.
Thyroid Hormone Mediated Modulation of Energy Expenditure.
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DOI：
10.3390/ijms160716158
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发表时间：
2015-07-16
影响因子：
5.6
通讯作者：
Celi FS
中科院分区：
文献类型：
--
作者：
Vaitkus JA;Farrar JS;Celi FS
甲状腺激素（TH）对线粒体和能量消耗（EE）有不同的影响，引起了人们的极大兴趣和研究努力，以了解和利用这些作用来改善和治疗代谢紊乱，如肥胖和糖尿病。对ATP利用的直接影响是由于TH对代谢周期和增加细胞膜离子通透性的作用。然而，大多数TH诱导的EE被认为是间接影响的结果，这反过来又增加了EE的能力。本文讨论了TH对EE的直接作用，并重点介绍了TH的间接作用，包括线粒体生物发生和通过线粒体解偶联机制降低代谢效率。TH类似物和T2的代谢作用也在EE靶向调节的背景下进行了讨论。最后，简要介绍了TH对代谢作用的临床相关性。
Thyroid hormone (TH) has diverse effects on mitochondria and energy expenditure (EE), generating great interest and research effort into understanding and harnessing these actions for the amelioration and treatment of metabolic disorders, such as obesity and diabetes. Direct effects on ATP utilization are a result of TH’s actions on metabolic cycles and increased cell membrane ion permeability. However, the majority of TH induced EE is thought to be a result of indirect effects, which, in turn, increase capacity for EE. This review discusses the direct actions of TH on EE, and places special emphasis on the indirect actions of TH, which include mitochondrial biogenesis and reduced metabolic efficiency through mitochondrial uncoupling mechanisms. TH analogs and the metabolic actions of T2 are also discussed in the context of targeted modulation of EE. Finally, clinical correlates of TH actions on metabolism are briefly presented.