TONOTOPIC MAPS OBTAINED FROM THE SURFACE OF THE DORSAL COCHLEAR NUCLEUS OF THE HAMSTER AND RAT
TONOTOPIC MAPS OBTAINED FROM THE SURFACE OF THE DORSAL COCHLEAR NUCLEUS OF THE HAMSTER AND RAT
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DOI：
10.1016/0378-5955(91)90013-y
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发表时间：
1991-01-01
期刊：
影响因子：
2.8
通讯作者：
LAZOR, J
中科院分区：
文献类型：
--
作者：
KALTENBACH, JA;LAZOR, J
在叙利亚金黄地鼠和白化大鼠的耳蜗背核(DCN)表面定位了强直性组织。这项研究的目的是描述这两个物种之间存在的精细图谱特征的比较异同，并区分显示高度恒定性的特征和显示同一物种个体之间显著差异的特征。总体而言，这两个物种的紧张性组织具有内侧梯度的特征，其中高CFs位于内侧，而低CFs位于外侧。每个物种内的图谱在梯度的斜率上以及在等频率等高线的首选吻尾方向上都显示出高度的稳定性。但不同树种间的树种间CF梯度斜率存在显著差异。在大鼠中，CFS向外侧末端下降的速度几乎是仓鼠的两倍，尽管这两个物种的DCN宽度没有明显差异。选择频率范围的区域的精确配置也显示出相当大的个体差异，并定义了每种动物独一无二的紧张性组织的“微结构”。这些发现对DCN发育的概念和听神经的神经支配方式的含义进行了讨论。
Tonotopic organization was mapped over the surface of the dorsal cochlear nucleus (DCN) on the Syrian golden hamster and albino rat. The purpose of this study was to describe comparative similarities and differences in fine map features that exist between these two species, and to differentiate features which show a high degree of constancy from those which show significant variations across individuals of the same species. In general, the tonotopic organization seen in both species was characterized by a mediolateral gradient in which high CFs were located medially and low CFs laterally. Maps within each species displayed a high degree of constancy both in the slopes of the gradient as well as in the preferred rostrocaudal orientation of isofrequency contours. However, between species significant differences were seen in the slope of the CF gradient. In the rat, CFs declined toward the lateral extremity at a rate which was nearly twice that seen in the hamster, despite the fact that there were no apparent differences in the width of the DCN in these two species. The precise configuration of areas subtending selected frequency ranges also showed considerable individual variation and defined a 'microstructure' of tonotopic organization that was unique for each animal. The implications of these findings on concepts of DCN development and modes of innervation by the auditory nerve are discussed.