Myc activates telomerase
Myc activates telomerase
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DOI：
10.1101/gad.12.12.1769
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发表时间：
1998-06-15
影响因子：
10.5
通讯作者：
Hannon, GJ
中科院分区：
文献类型：
--
作者：
Wang, J;Xie, LY;Hannon, GJ
端粒的维持被认为是人类肿瘤发生的必要前提。端粒酶本身就是肿瘤细胞的标志，但在肿瘤转化过程中激活该酶的基因变化仍然是一个谜。在这里，我们展示了Myc诱导正常人乳腺上皮细胞(HMECs)和正常人二倍体成纤维细胞的端粒酶。MYC增加端粒酶限制性亚基hEST2(hTRT/TP2)的表达，Myc和hEST2均可延长HMEC的寿命。Myc激活端粒酶的能力可能与其促进肿瘤形成的能力有关。
Telomere maintenance has been proposed as an essential prerequisite to human tumor development. The telomerase enzyme is itself a marker for tumor cells, but the genetic alterations that activate the enzyme during neo-plastic transformation have remained a mystery. Here, we show that Myc induces telomerase in both normal human mammary epithelial cells (HMECs) and normal human diploid fibroblasts. Myc increases expression of hEST2 (hTRT/TP2), the limiting subunit of telomerase, and both Myc and hEST2 can extend the life span of HMECs. The ability of Myc to activate telomerase may contribute to its ability to promote tumor formation.