Recurrence Season Impacts the Survival of Epithelial Ovarian Cancer Patients
Recurrence Season Impacts the Survival of Epithelial Ovarian Cancer Patients
复制标题
复发季节影响上皮性卵巢癌患者的生存
DOI：
10.7314/apjcp.2014.15.4.1627
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发表时间：
2014-01-01
影响因子：
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通讯作者：
Wu, Xiong-Zhi
中科院分区：
文献类型：
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作者：
Liu, Xiao-Hui;Man, Ya-Nan;Wu, Xiong-Zhi
背景：多项研究表明，诊断季节会影响某些癌症的预后，例如前列腺癌、结肠癌和乳腺癌。本回顾性研究旨在探讨诊断和复发季节是否影响上皮性卵巢癌患者的预后。方法：对2005年1月至2010年8月161例上皮性卵巢癌患者进行分析，随访至2013年8月。采用Kaplan-Meier生存曲线和时序检验进行生存分析。进行多变量分析以确定独立的预后因素。结果：影响上皮性卵巢癌患者总生存的预后因素包括年龄、临床分期、病理类型、组织学分级、初次手术后残留病灶、复发季节和辅助化疗周期。此外，临床分期、组织学分级、初次手术后残留病灶、复发季节和辅助化疗周期也影响上皮性卵巢癌患者的无进展生存期。 4月至11月复发月患者的诊断季节总生存期为47个月，比12月至3月复发月的患者（19个月）长（P < 0.001）。 4月至11月和12月至3月复发患者的中位无进展生存期分别为20个月和8个月（P < 0.001）。结论：复发季节影响上皮性卵巢癌患者的生存。然而，确诊季节似乎并未产生重大影响。
Background: Several studies indicated that the diagnosis season affects the prognosis of some cancers, such as examples in the prostate, colon and breast. This retrospective study aimed to investigate whether the diagnosis and recurrent season impacts the prognosis of epithelial ovarian cancer patients. Methods: From January 2005 to August 2010, 161 epithelial ovarian cancer patients were analyzed and followed up until August 2013. Kaplan-Meier survival curves and the log-rank test were used to make the survival analysis. Multivariate analysis was conducted to identify independent prognostic factors. Results: The prognostic factors of overall survival in epithelial ovarian cancer patients included age, clinical stage, pathological type, histological grade, residual disease after primary surgery, recurrent season and adjuvant chemotherapy cycles. Moreover, clinical stage, histological grade, residual disease after primary surgery, recurrent season and adjuvant chemotherapy cycles also impacted the progression-free survival of epithelial ovarian cancer patients. The diagnosis season overall survival of patients with recurrent month from April to November was 47 months, which was longer (P < 0.001) than that of patients with recurrence month from December to March (19 months). Median progression-free survival of patients with recurrence month from April to November and December to March was 20 and 8 months, respectively (P < 0.001). Conclusion: The recurrence season impacts the survival of epithelial ovarian cancer patients. However, the diagnosed season does not appear to exert a singnificant influence.