Synthetic surfaces for human embryonic stem cell culture
Synthetic surfaces for human embryonic stem cell culture
复制标题
DOI：
10.1016/j.jbiotec.2010.01.016
复制
发表时间：
2010-04-01
影响因子：
4.1
通讯作者：
Ruoslahti, Erkki
中科院分区：
文献类型：
--
作者：
Kolhar, Poornima;Kotamraju, Venkata Ramana;Ruoslahti, Erkki
人类胚胎干细胞(HESCs)具有独特的自我更新能力和多能性，在生物医学领域具有广阔的应用前景。HESCs及其衍生物的成功临床应用需要在完全限定的环境中培养这些细胞。我们开发了一种新的基于多肽的表面，它使用高亲和力的环状RGD多肽在化学定义的条件下培养人胚胎干细胞。(C)2010爱思唯尔B.V.保留所有权利。
Human embryonic stem cells (hESCs) have numerous potential biomedical applications owing to their unique abilities for self-renewal and pluripotency. Successful clinical application of hESCs and derivatives necessitates the culture of these cells in a fully defined environment. We have developed a novel peptide-based surface that uses a high-affinity cyclic RGD peptide for culture of hESCs under chemically defined conditions. (C) 2010 Elsevier B.V. All rights reserved.