Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart
Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart
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DOI：
10.1016/j.ydbio.2005.02.012
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发表时间：
2005-05-01
影响因子：
2.7
通讯作者：
Kirby, ML
中科院分区：
文献类型：
--
作者：
Waldo, KL;Hutson, MR;Kirby, ML
心脏的动脉极是心室肌作为主动脉和肺动脉干的血管平滑肌被膜继续存在的区域。已经表明，动脉极心肌。来源于心脏第二野主动脉和肺动脉干的平滑肌膜来源于神经嵴。然而，这种神经嵴来源的平滑肌没有延伸到动脉极心肌，在主动脉和肺动脉干的底部留下了一个未知来源的血管平滑肌覆盖的区域。通过组织标记和血管平滑肌标记，我们发现次级心野除了为心流出道提供心肌外，还产生前瞻性平滑肌，形成主动脉和肺动脉干的近端壁。因此，动脉极有两条接缝：一是心肌与心野源性平滑肌的连接处；第二种是心野源性平滑肌与神经嵴源性平滑肌。这两个接缝都是在马特范氏综合症和其他综合症中经常发生主动脉夹层的地方。(c) 2005爱思唯尔公司版权所有。
The arterial pole of the heart is the region where the ventricular myocardium continues as the vascular smooth muscle tunics of the aorta and pulmonary trunk. It has been shown that the arterial pole myocardium. derives from the secondary heart field and the smooth muscle tunic of the aorta and pulmonary trunk derives from neural crest. However, this neural crest-derived smooth muscle does not extend to the arterial pole myocardium leaving a region at the base of the aorta and pulmonary trunk that is invested by vascular smooth muscle of unknown origin. Using tissue marking and vascular smooth muscle markers, we show that the secondary heart field, in addition to providing myocardium to the cardiac outflow tract, also generates prospective smooth muscle that forms the proximal walls of the aorta and pulmonary trunk. As a result, there are two seams in the arterial pole: first, the myocardial junction with secondary heart field-derived smooth muscle; second, the secondary heart field-derived smooth muscle with the neural crest-derived smooth muscle. Both of these seams are points where aortic dissection frequently occurs in Mat-fan's and other syndromes. (c) 2005 Elsevier Inc. All rights reserved.